조직학적으로 진단된 호산구성 간농양 19 예의 임상적 특성 단일 센터 경험 = Clinical Characteristics of 19 Cases of Biopsy - proven Eosinophilic Liver Abscess Single Center Experience

다국어 초록 (Multilingual Abstract)

Background/Aims: Up to 29% of patients with severe ulcerative colitis (UC) fail to respond to steroids acutely and thus, require surgery. The aims of this study were to elucidate the predicting factors suggesting medical treatment failure in patients with severe UC and to evaluate whether cyclooxygenase (COX)-2 expression can predict the prognosis of these patients. Methods: Thirty-six patients with severe UC were enrolled in this study. After seven-day-treatment with high-dose intravenous steroids, they were classified into three groups according to the level of respondence: complete responders (CR), incomplete responders (IR), and treatment failures (TF). Then, clinical, laboratory, histological (including COX-2 expression), and endoscopic indices of those 3 groups were compared. Results: Distal colitis tended to be more frequent in the CR. However, the other clinical, laboratory, histological and endoscopic indices of the three groups were similar. The expression rates of COX-2 were similar in the three groups and showed a significant correlation with the histological severity. Conclusions: The extent of disease can be a good predictor of outcome of steroid therapy for severe UC but COX-2 expression can not predict the outcome of the therapy. (Korean J Gastroenterol 2001;38:29-36)