임신중기 모체혈청 베타 인체융모 성선자극홀몬치를 이용한 염색체이상 태아의 산전 선별검사 = Prenatal Screening Test for Fetal Chromosomal Abnormalities with Maternal Serum Beta Human Chorionic Gonadotropin Levels in Midtrimester Pregnancy

다국어 초록 (Multilingual Abstract)

A commercially available radioimmunoassay kit was used to measure the b-subunit of human chorionic gonadotropin (hCG) in maternal serum from 1341 normal singleton pregnancies and 5 chromosomally abnormal pregnancies (four cases of 45,X and one 45,X/46, XX). The purpose of this study was to investigate maternalserum screening with b-hCG as a screening with b-hCg as a screening test for fetal chromosomal abnormalities. The b-hCG levels decreases with each week of gestation from 15 to 20 weeks. The median values of b-hCg for each week of gestation were as follows: 17.0(15wk), 15.0(16wk), 11.2(17wk), 9.7(18wk), 8.8(19wk) and 7.9(20wk) IU/ml respectively. The b-hCg levels of 4 cases with 45, X were 6.2, 2.1, 1.7, 1.2 multiples of the median (MoM), respectively. The b-hCG level in the one case of 45, X/46, XX was 0.2 MoM. Our median b-hCG values in the second trimester can be used for selecting high-risk patients for fetal chromosomal abnormalities. Further evaluation for the efficiency of b-hCG in screening for other aneuploidies is needed.