심혈관계질환의 위험지표로서Omega-3 Index에 대한 올바른 이해 및 한국인에의 적용 = Omega-3 Index as a risk factor for cardiovascular diseases and its application to Korean population

국문 초록 (Abstract)

오메가-3 다가 불포화지방산인 eicosapentaenoic acid(EPA; C20:5)와 docosahexaenoic acid(DHA; C22:6)는 심혈관계질환으로 인한 사망을 예방하는 영양소로 잘 알려져 있다. 최근에는 오메가-3 지방산이 심혈관계질환뿐 아니라 뇌졸중을 예방하는데도 도움이 된다는 연구결과가 보고되고 있으며, 이러한 오메가-3 지방산의 효과는 항부정맥, 항염증, 혈액응고 억제, 지단백질 농도 저하 등과 관련이 있다고 한다. Omega-3 Index는 오메가-3 지방산의 체내 수준을 나타내는 유일한 표준 혈액 검사로 적혈구의 EPA와 DHA 수준을 의미한다. Omega-3 Index는 섭취한 오메가-3 지방산과 비례할 뿐 아니라, 심장근육의 오메가-3 지방산 농도와도 비례함하고, 심혈관계질환의 위험도와 음의 상관관계를 가진다고 알려져 심혈관계질환의 위험지표로 활용되고 있다. 권장섭취량인 1g의 오메가-3 지방산으로 얻을 수 있는 8-10% Omega-3 Index가 심혈관계질환의 예방을 위한 적정 목표치로 설정되었다. 한국인에게도 Omega-3 Index는 활용가능하나 목표치는 상향 조정이 필요하다고 사료된다.

다국어 초록 (Multilingual Abstract)

Of all known dietary factors, long-chain omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) may be the most protective against death from cardiovascular disease. Evidence continues to accrue for benefits of omega-3 fatty acids in the prevention of coronary heart disease and stroke. Anti-arrhythmogenic, anti-inflammatory, anti-thrombotic and hypolipidemic effects of omega-3-fatty acids are emerging as the most likely explanation. New evidence has confirmed and refined the cardioprotective risk factor of Omega-3 Index, the only standardized blood test of omega-3 fatty acids measuring content of erythrocyte eicosapentaenoic and docosahexaenoic acids. Current evidence suggests that individuals with coronary artery disease may reduce their risk of sudden cardiac death by increasing their intake of long-chain omega-3 fatty acids by approximately 1 g per day and achieving a target range of 8-10% Omega-3 Index. However, target range of Omega-3 Index for Koreans may be higher than 10%.

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