In order to prove the anticonvulsive effect of Borneolum fragrance in convulsion-induced mice, experiments were performed on anticonvulsive effect, GABA level, glutamic acid level, GABA-T activity and GAD activity.
The results were obtained as follow...
In order to prove the anticonvulsive effect of Borneolum fragrance in convulsion-induced mice, experiments were performed on anticonvulsive effect, GABA level, glutamic acid level, GABA-T activity and GAD activity.
The results were obtained as follows :
1. As far as anticonvulsive effect was concemed, on the convulsion induced by pentylenetetrazole it was significant comparing to the control group.
2. GABA level was increased significantly in mice.
3. Glutamic acid level was decreased significantly in mice.
4. GABA-T activity was decreased by Borneolum fragrance.
5. Borneolum fragrance was not effective in GAD activity.
From above result, Borneolum fragrance had significant effects on convulsion induced by pentylenetetrazole, so it is expected to clinical application on convulsive diseases such as epilepsy.