Dicofenac-sodium(sodium［o-(2,6-dichlorophenyl)amino］pheny1］acetate)의 硬皮吸收에 미치는 Propylene glycol의 影響 = Effect of propylene glycol on the Percutaneous Absorption of Diclofenac-sodium (sodium［o-(2,6-dichlorophenyl)amino］pheny1］acetate)

다국어 초록 (Multilingual Abstract)

To study the effect of Propylene glycol on the percutaneous absorption of Diclofenac-sodium, the percutaneous absorption of diclofenac-sodium was carried out on rabbit dorsal skin under occlusions in addition of each Propylene glycol concentration(0, 2, 5, 10 and 20w/w％).
The percutaneous absorption of diclofenac-sodium after percutaneous application of preparation for 6 hours (3㎝×3㎝ area, 1.0g of 10w/w％ Diclofenac-sodium percutaneous application of preparation) was significantly increased by increasing the concentration of Propylene glycol. The percutaneous absorption of Diclofenac-sodium with 10％ Propylene glycol was increased in an approximate 3.37 and 1.74 fold higher than control preparation in the parameters, Cmax and AUC.
But the percutaneous absorption of Dilofenac-sodium with 20％ Propylene glycol was relatively lower than control preparation.
The absolute bioavailability (Fabs) of Dilofenac-sodium after percutaneous application with each concentration of Propylene glycol was respectively as follows ; 0％: 14.68±2.03％, 2％: 18.25±2.30％, 5％: 24.64±3.42％, 10％: 25.55±4.31％, 20％: 11.89±2.06％)