A 55-year-old right-handed woman presented initially with mild amnestic and depressive episodes but developed slowly progressive neurobehavioral symptoms indicative of posterior cortical atrophy in ensuing years. A more detailed neurobehavioral test s...
A 55-year-old right-handed woman presented initially with mild amnestic and depressive episodes but developed slowly progressive neurobehavioral symptoms indicative of posterior cortical atrophy in ensuing years. A more detailed neurobehavioral test suggested predominant right temporo-parietal dysfunction with executive functional deficits. SPECT and MRI findings revealed right unilateral temporo-parietal involvement. Cholinesterase inhibitor administration for 14 months led to amelioration of cognitive dysfunction on follow-up neuropsychologic evaluation. We suggest that cases of posterior cortical atrophy or visual variant of Alzheimer's disease may be responsive to cholinesterase inhibitor therapy.