Structural insights into the molecular mechanism of ABC transporters

다국어 초록 (Multilingual Abstract)

ABC (ATP-binding cassette) transporters mediate the translocation of a large variety of molecules across lipid bilayers andare directly driven by energy from ATP hydrolysis. Since the first crystal structure of an ABC transporter, the E. coli vitaminB12 transporter BtuCD, was reported in 2002, over thirty structures of ABC proteins in different functional states have beendetermined by X-ray crystallography or by single particle cryo-electron microscopy reconstruction. In this review, structuraldetails of ABC transporters, the maltose transporter of Escherichia coli and the P-glycoprotein of Caenorhabditis elegans,are discussed to understand the molecular mechanism of ABC importers and exporters, respectively.

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