서울에서 발생한 Human Metapneumovirus의 유행양상

다국어 초록 (Multilingual Abstract)

The human meta pneumovirus(hMPV) is a recently identified Paramyxovi rus associated with acute respiratory tract infect ions(ARIs) ranging from upper ARIs to severe bronchiolitis and pneumonia in humans. We studied the prevalence of this new virus in Seoul from 2005 to 2006 A total of 757 specimens were collected by nasopharyngeal swab from ARI patients and were tested fo1' the presence of hMPV by reverse transcription-PCR. Of these‘ 28 were detected the L gene of hMPV. The age range of the patients with hMPV infection was 1 months to 67 years with similar numbers of females (59 .3%) and males(40.7%) . The main symptoms were cough(100%) , fever (82 .1%) , nasal mucus(67.8%) ‘ vomit(25%) . diarrhoea( 21. 4%). and difficult breathing(21. 4%) and the main diagnosis we1'e pneumonia, bronchioli tis, nasoharyngiti ts, and rhmJtls Virus activity peaked in March and May. Phylogenetic analysis of the N gene confirmed the existence and si multaneous circulation within one epidemic season of hMPV isolates belonging to two genetic lineages.

참고문헌 (Reference)

1 "Use of the P Gene to genotype Human Metapneumovirus Identifies 4 Viral Subtypes" 190 : 1913-1918, 2004

2 "Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses" 18 : 141-146, 2005

3 "Molecular assays for detection of human metapneumovirus" 41 (41): 100-105, 2003

4 "Human metapneumovirus infections in young and elderly aduts" 187 (187): 785-790, 2003

5 "Human metapneumovirus detection in patients with severe acute respiratory syndrome" 9 (9): 1058-1063, 2003

6 "Human Metapneumovirus infections in Hospitalized children" 9 (9): 634-640, 2003

7 "High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates" 41 (41): 3043-3045, 2003

8 "Genetic Diversity of human metapneumovirus over 4 consecutive years in Australia" 193 (193): 1630-1633, 2006

9 "Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong" 9 (9): 628-633, 2003

10 "Antigenic and genetic variability of human metapneumoviruses" 10 (10): 658-666, 2004

11 "A newly discovered human Penumovirus isolated from young children with respiratory tract disease" 7 (7): 719-724, 2001