천궁의 품질평가를 위한 유효성분의 함량분석 = Quantitative Analysis for the Quality Evaluation of Active Ingredients in Cnidium Rhizome

다국어 초록 (Multilingual Abstract)

The current definition of Cnidium Rhizome is the rhizome or the rhizome which is blanched by hot water of Cnidium officinale Makino or Ligusticum chuanxiong Hort. in the Korean Pharmacopoeia. However, the marker compound of Cnidium Rhizome is not specified, there are difficulties for quality control. Therefore, in this study we established the simultaneous determination method that analyze 4 different compounds by the HPLC-PDA. These compounds comprise chlorogenic acid, ferulic acid, senkyunolide A and z-ligustilide. As the result of the analysis, z-ligustilide has been shown highest content followed by senkyunolide A, ferulic acid and chlorogenic acid. These results can be exploited for a basic marker compounds of Cnidium Rhizome and for the legislation on the regulation and control of herbal medicines.

목차 (Table of Contents)

• 실험 방법
• 실험결과 및 고찰
• 결 론

참고문헌 (Reference)

1 이지혜, "천궁(Cnidium officinale)의 휘발성 향기성분 및 유리기 소거활성" 한국식품과학회 34 (34): 330-338, 2002

2 식품의약품안전평가원, "의약품등 시험방법 밸리데이션 가이드라인"

3 식품의약품안전청, "생약(한약)제제의 성분 프로파일 설정 가이드라인"

4 이명희, "생강(Zingiber officinale Roscoe)의 숙성기간에 따른 품질특성" 한국식품위생안전성학회 27 (27): 479-486, 2012

5 김재철, "고랭지약초연구(천궁, 당귀, 강활, 고본)" 봉화고냉지약초시험장 35-, 2012

6 國家藥典委員會, "中華人民共和國藥典" 國藥科技出版社 2010

7 Dewanto, V, "Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity" 50 : 3010-, 2002

8 백일성, "The Effects of Cnidium Officinale extract on the Ischemic Stroke and Oxidative Neural Damage in Rats' Brain" 대한본초학회 18 (18): 5-46, 2003

9 Kim, W. Y, "Steaming of ginseng at high temperature enhances biological activity" 63 : 1702-, 2000

10 Yan, R, "Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography" 37 : 87-, 2005

11 L.Z. Lin, "Liquid chromatographic electrospray mass spectrometric study of the phthalides of Angelica sinensis and chemical change of Zligustilide" 810 : 71-, 1998

12 Or, T. C, "Isolation and identification of anti-inflammatory constituets from Ligusticum chuanxing and their underlying mechanisms of action on microglia" 60 : 823-, 2011

13 Mahesh, R, "Free radical scavenging activities of Cnidium officinale Makino and Ligusticum chuanxing Hort. methanolic extracts" 6 : 323-, 2010

14 Cheng, C. Y, "Ferulic acid reduces cerebral infarct through its antioxidative and anti-inflammatory effects following transient focal cerebral ischemia in rats" 36 : 1105-, 2008

15 Kim, K. W, "Comparison on the phthalides content of Cinidil Rhizoma and Angelicae Radix cultivated in korea and china" 14 : 24-, 2001

16 Jeong, J. B, "Antioxidant activity in essential oils of Cnidium officinale makino and Ligusticum chuanxing Hort and their inhibitory effects on DNA damage and apoptosis induced by ultraviolet B in mammalian cell" 33 : 41-, 2009