백서위산분비에 (白鼠胃酸分泌) 미치는 Methylxanthine 의 작용기전에 (作用機轉) 관한 연구 = Studies on the Actions of Methylxanthines on the Gastric Secretion in the Rat

다국어 초록 (Multilingual Abstract)

The author studied the effects of methylxanthine on the gastric secretion and ulcer formation and obtair.ed the fo!lowing results. 1. Gastric secretion nf rats collected in the stomach after pylorus ligation ivas analized. Both caffeir.e and amir,oply!!ine inhibited gastric secretion (volume, acid concer.tration and acid output), respectively. Caffeine avas four fold more effective than aminophylline. Hoivever, the degree of inhibition by either caffeine or aminophyylline was dose-dependent, 2 Iz Shay rats, both caffeine and arninophylline aIso shoived the dose-dep ndent inhibition in the forma'.ion oi u!cers in the mucosa and rumen portions. 3 The resti aint st:es u!cer was not induced in the rumen but in the muco=a portion. The formation of stress uicers was not prevented by small does hut by large doses of methylxani- 11CS. It migl t be umn.ar.zed that tbere is a pecies differences in the action of methy]xanthine o; the gastric sec: etio,.