고압산소요법이 급성 출혈성 쇼크상태의 흰쥐에 미치는 영향 = EFFECTS OF HYPERBARIC OXYGEN THERAPY IN A RAT MODEL OF ACUTE HEMORRHAGIC SHOCK

다국어 초록 (Multilingual Abstract)

The severe degree of hypotension which is produced in experimental shock preparations is associated with tissue hypoxia and metabolic acidosis. Decreased oxygen delivery and cellular hypoxia are important factors in the pathophysiology of hemorrhagic shock. It is possible that adverse effects of prolonged hypotension may be ameliorated by increasing the oxygen content of the arterial blood.
We studied the effects of 100% oxygen at 1 and 3 ATA (atmosphere absolute) in a severe model of hemorrhagic shock induced by bleeding 40% of the total blood volume in rats. Post-treatment with 100% oxygen at 1 and 3 ATA maintained mean arterial blood pressure (MABP) in hemorrhaged rats at significantly higher values compared to untreated controls (P<0.05 at 1 and 3 ATA). Treatment with oxygen attenuated the decrease in base excess of the arterial blood. Base excess has been shown to be a sensitive measure of the degree and duration of inadequate perfusion. Hemorrhagic shock induced metabolic acidosis and treatment with oxygen attenuated the decrease in pH of the arterial blood. Hemorrhaged rats treated with oxygen also exhibited a higher survival rates (88% at 1 ATA and 100% at 3 ATA) than untreated shock rats. Our results indicate that 100% oxygen in normobaric and hyperbaric conditions exerts important beneficial effects in hemorrhagic shock and may be a useful drug for the treatment of this conditions.