Lithium Carbonate의 造血能에 미치는 影響 = Effect of Lithium Carbonate on Hematopoiesis

국문 초록 (Abstract)

著者는 흰 숫쥐에 lithium carbonate를 經口的으로 4週間 投與하고 末稍血液像과 骨髓像 및 赤血球 ^59Fe 利用率에 미치는 影響을 檢討하였으며 아울러 抗癌劑인 cyclophosphamide 投與에 따르는 造血障碍를 lithium carbonate로써 矯正이 可能한지 그 與否를 檢討하기 위해 이 實驗을 企圖했으며 다음과 같은 成績을 얻었다. 즉, 體重 1kg 當 15mg의 lithium carbonate를 投與한 第 Ⅱ群에서는 第 Ⅰ群(對照群)에 比하여 末梢血液과 骨髓에서 有意한 好中球增多症이 있었다. kg當 150mg의 cyclophosphamide를 1回 投與한 第 Ⅱ群에서는 一時的인 有意한 網赤血球減少와 好中球減少가 있었으나 cyclophosphamide를 投與한 후 lithium carbonate를 4週間 投與한 第 Ⅳ群에서는 稍末血液像이 正常化되었다. 이러한 事實은 lithium carbonate가 cyclophosphamide에 依한 造血障碍을 矯正할 수 있음을 示唆하는 것이다.

다국어 초록 (Multilingual Abstract)

The hematopoietic effects of lithium carbonate was studied with the following results. In rats administered lithium carbonate orally at a dose of 15mg/kg daily for 4 weeks, a significant enhancement of absolute neutrophil count both in the peripheral blood and bone marrow was noted. However, no appreciable alterations were found in hemoglobin, reticulocyte count, platelet, total marrow nucleated cell count, absolute erythroid cell count, absolute megakaryocyte count, and erythrocyte ^59Fe incorporation rate. The rats treated with an oral administr tion of cyclophosphamide at a dose of 150mg/kg once revealed both a statistically significant transient reticulocytopenia and neutropenia, but the rats given by cyclophosphamide followed by lithium carbonate for 4 weeks demonstrated restoration of depressed peripheral blood picture, suggesting lithium carbonate being offset the hematologically suppressive effect of cyclophosphamide.