임신랫드에 투여한 임마혈청성성선자극호르몬이 황체 및 태아에 미치는 영향 = Effects of Exogenous Pregnant Mare Serum Gonadotrophin(PMSG) on the Corpus Luteum and Fetus in Pregnant Rats

다국어 초록 (Multilingual Abstract)

The present study was designed to determine the effect of PMSG administration to pregnant rats on the dam and its fetus including the corpora lutea, the body weight and resorption of the fetus and the malformations of the fetus in skeletal development when a single dose of PMSG 6.25, 12.5, 25, 50 or 100 IU administered on day 3, 6, 9, 12 or 15 of pregnancy.
The results were summarized as follows:
1. A single administration of PMSG on day 3, 6, 9, 12 or 15 resulted in increasing the number of corpora lutea up to day 6, no effect being obtained on day 9, 12 or 15 of pregnancy.
2. A single administration of PMSG on day 3, 6, 9, 12 or 15 resulted in fetal resorption on days 6, 9 and 12 and inhibition of implantation on days 3 and 6 of pregnancy.
3. A single administration of PMSG on day 3, 6, 9, 12 or 15 resulted in decrease in fetal body weight on day 9 or 15 but increase or decrease on day 12 of pregnancy.
4. A single administration of PMSG on day 3, 6, 9, 12 or 15 did not result in the skeletal malformations and variations and abnormal ossifications of the fetus but the extra 14 ribs observed in 3 rats treated with PMSG 25 IU on day 9 and 15 and saline solution on day 12 of pregnancy, respectively.
5. It is suggested that PMSG administration to pregnant rats induced the resorption of the fetus and inhibited the implantation but had no effect on skeletal malformations and variations and abnormal ossifications of the fetus in skeletal development.