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    저항성 운동이 OLETF 쥐의 혈청 염증반응지표 및 고환조직의 CatSper 1-4 단백질 발현에 미치는 영향 = Effects of Resistance Training on Serum Inflammatory Markers and CatSper 1-4 Protein Expression in Testis of OLETF Rats

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    https://www.riss.kr/link?id=A104182287

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    다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

    PURPOSE: This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats.
    METHODS: Male OLETF rats were divided into two groups; control group (n=12), resistance exercise group (n=12). The exercise group performed a total of 8 weeks of moderate intensity resistance exercise on a 1.35 m vertical ladder with weights secured to their tails.
    RESULTS: The results of this study was following; The exercise group showed a significant decreased in the inflammatory (IL-1β, IL-6, TNF-α) levels as compared to the control group. But CRP was no significant difference between control and exercise groups. Also, CatSper 1 and 2 were significantly increased in the exercise group compared to the control group, whereas CatSper 3, 4 were no significant difference between both groups.
    CONCLUSIONS: This study suggests that resistance exercise training can contribute to reduce pro-inflammatory responses in whole body and it affects male reproductive function by improve sperm quality and CatSper protein expression.
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    PURPOSE: This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats. METHODS: Male OLETF rats were divided into two groups; control group (n=12), resistance exerci...

    PURPOSE: This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats.
    METHODS: Male OLETF rats were divided into two groups; control group (n=12), resistance exercise group (n=12). The exercise group performed a total of 8 weeks of moderate intensity resistance exercise on a 1.35 m vertical ladder with weights secured to their tails.
    RESULTS: The results of this study was following; The exercise group showed a significant decreased in the inflammatory (IL-1β, IL-6, TNF-α) levels as compared to the control group. But CRP was no significant difference between control and exercise groups. Also, CatSper 1 and 2 were significantly increased in the exercise group compared to the control group, whereas CatSper 3, 4 were no significant difference between both groups.
    CONCLUSIONS: This study suggests that resistance exercise training can contribute to reduce pro-inflammatory responses in whole body and it affects male reproductive function by improve sperm quality and CatSper protein expression.

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    참고문헌 (Reference)

    1 윤진환, "트레드밀 운동이 수컷 흰쥐의 혈중 testosterone, 정자의 운동성 및 고환 조직 CatSper 1, 2 단백질 발현에 미치는 영향" 한국체육학회 56 (56): 527-539, 2017

    2 장문석, "人蔘이 수컷 생쥐의 정자 수와 CatSper3, 4 단백질 발현에 미치는 영향" 대한본초학회 27 (27): 47-51, 2012

    3 Lee SH, "Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistancetrained rats" 96 (96): 1097-1104, 2004

    4 Hajizadeh Maleki B, "The effects of three different exercise modalities on markers of male reproduction in healthy subjects : a randomized controlled trial" 153 (153): 157-174, 2017

    5 Ding GL, "The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis" 17 (17): 948-953, 2015

    6 Laake JP, "The association between depressive symptoms and systemic inflammation in people with type 2 diabetes : findings from the south london diabetes study" 37 (37): 2186-2192, 2014

    7 Zeinab AminiLari, "The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women" 대한당뇨병학회 41 (41): 205-212, 2017

    8 Suarez SS, "Sperm transport in the female reproductive tract" 12 (12): 23-37, 2006

    9 Ryan D. Russell, "Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes" American Diabetes Association 40 (40): 1256-1263, 2017

    10 Enzlin P1, "Sexual dysfunction in women with type 1 diabetes : long-term findings from the DCCT/ EDIC study cohort" 32 (32): 780-785, 2009

    1 윤진환, "트레드밀 운동이 수컷 흰쥐의 혈중 testosterone, 정자의 운동성 및 고환 조직 CatSper 1, 2 단백질 발현에 미치는 영향" 한국체육학회 56 (56): 527-539, 2017

    2 장문석, "人蔘이 수컷 생쥐의 정자 수와 CatSper3, 4 단백질 발현에 미치는 영향" 대한본초학회 27 (27): 47-51, 2012

    3 Lee SH, "Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistancetrained rats" 96 (96): 1097-1104, 2004

    4 Hajizadeh Maleki B, "The effects of three different exercise modalities on markers of male reproduction in healthy subjects : a randomized controlled trial" 153 (153): 157-174, 2017

    5 Ding GL, "The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis" 17 (17): 948-953, 2015

    6 Laake JP, "The association between depressive symptoms and systemic inflammation in people with type 2 diabetes : findings from the south london diabetes study" 37 (37): 2186-2192, 2014

    7 Zeinab AminiLari, "The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women" 대한당뇨병학회 41 (41): 205-212, 2017

    8 Suarez SS, "Sperm transport in the female reproductive tract" 12 (12): 23-37, 2006

    9 Ryan D. Russell, "Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes" American Diabetes Association 40 (40): 1256-1263, 2017

    10 Enzlin P1, "Sexual dysfunction in women with type 1 diabetes : long-term findings from the DCCT/ EDIC study cohort" 32 (32): 780-785, 2009

    11 Srikanthan P, "Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey" 96 (96): 2898-2903, 2011

    12 Kamezaki F, "Proposed cutoff level of waist circumference in Japanese men: evaluation by homeostasis model assessment of insulin resistance levels" 51 (51): 2119-2124, 2012

    13 Mazzilli R, "Prevalence of Diabetes Mellitus (DM) in a population of men affected by Erectile Dysfunction (ED)" 166 (166): e317-e320, 2015

    14 Gaskins AJ, "Physical activity and television watching in relation to semen quality in young men" 49 (49): 265-270, 2015

    15 Francesconi C, "Physical activity and exercise training in the prevention and therapy of type 2 diabetes mellitus" 128 (128): S141-S145, 2016

    16 Ehses JA, "Pancreatic islet inflammation in type 2 diabetes : from alpha and beta cell compensation to dysfunction" 115 (115): 240-247, 2009

    17 Keane KN, "Molecular events linking oxidative stress and inflammation to insulin resistance and β-cell dysfunction" 2015 : 181643-, 2015

    18 Fatani AJ, "Lutein dietary supplementation attenuates streptozotocin-induced testicular damage and oxidative stress in diabetic rats" 15 (15): 204-, 2015

    19 Shukla KK, "Ion channels in sperm physiology and male fertility and infertility" 33 (33): 777-788, 2012

    20 Tilg H, "Inflammatory mechanisms in the regulation of insulin resistance" 14 (14): 222-231, 2008

    21 Spranger J, "Inflammatory cytokines and the risk to develop type 2 diabetes : results of the prospective population-based European Prospective Investigation into Cancer and Nutrition(EPIC)-Potsdam Study" 52 (52): 812-817, 2003

    22 Karimi J, "Increased receptor for advanced glycation end products in spermatozoa of diabetic men and its association with sperm nuclear DNA fragmentation" 44 (44): 280-286, 2012

    23 Horii N, "Increased muscular 5α-dihydrotestosterone in response to resistance training relates to skeletal muscle mass and glucose metabolism in type 2 diabetic rats" 11 (11): e0165689-, 2016

    24 Rosety-Rodriguez M, "Home-based treadmill training improved seminal quality in adults with type 2 diabetes" 38 (38): 589-593, 2014

    25 Kiskac M, "Frequency and determinants of erectile dysfunction in Turkish diabetic men" 18 (18): 209-212, 2015

    26 Fink LN, "Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes" 56 (56): 1623-1628, 2013

    27 Zhou S, "Experimental Research on Therapeutic Efficacy of Traditional Chinese Medicine Shengjing Capsule Extracts in Treating Spermatogenesis Impairment Induced by Oxidative Stress" 22 : 50-56, 2016

    28 Rosety MÁ, "Exercise improved semen quality and reproductive hormone levels in sedentary obese adults" 34 (34): 603-607, 2017

    29 Miller EG, "Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes" 117 (117): 1669-1678, 2017

    30 Hopps E, "Effects of exercise on inflammation markers in type 2 diabetic subjects" 48 (48): 183-189, 2011

    31 Hayashino Y, "Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes : a meta-analysis of randomized controlled trials" 63 (63): 431-440, 2014

    32 Molanouri Shamsi M, "Effect of resistance exercise training on expression of Hsp70 and inflammatory cytokines in skeletal muscle and adipose tissue of STZ-induced diabetic rats" 21 (21): 783-791, 2016

    33 Guneli E, "Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats" 40 (40): 354-360, 2008

    34 Palmer NO, "Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function" 302 (302): E768-E780, 2012

    35 Ricci G, "Diabetic rat testes : morphological and functional alterations" 41 (41): 361-368, 2009

    36 Amaral S, "Diabetes and the impairment of reproductive function : possible role of mitochondria and reactive oxygen species" 4 (4): 46-54, 2008

    37 Giugliano F, "Determinants of erectile dysfunction in type 2 diabetes" 22 (22): 204-209, 2010

    38 Jin JL, "Catsper3and catsper4 encode two cation channel-like proteins exclusively expressed in the testis" 73 (73): 1235-1242, 2005

    39 Jin J, "Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse" 77 (77): 37-44, 2007

    40 Ren D, "Calcium signaling through CatSper channels in mammalian fertilization" 25 (25): 165-175, 2010

    41 Pradhan AD, "C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus" 286 (286): 327-334, 2001

    42 Ren D, "A sperm ion channel required for sperm motility and male fertility" 413 (413): 603-609, 2001

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