목 적: 저성선자극호르몬 성선저하증은 남성불임의 흔치 않은 원인이다. 저자들은 성선자극호르몬 특히 인간융 모성선자극호르몬 (Human chorioinc gonadotropin: hCG)/인간폐경성선자극호르몬 (Human ...
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https://www.riss.kr/link?id=A100815988
주영민 (관동대학교) ; 김태홍 (관동대학교) ; 서주태 (관동대학교) ; Joo, Young-Min ; Kim, Tae-Hong ; Seo, Ju-Tae
2009
Korean
저성선자극호르몬 성선저하증 ; 성선자극호르몬 ; 가임 ; 임신 성공
KCI등재,SCOPUS,ESCI
학술저널
219-224(6쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
목 적: 저성선자극호르몬 성선저하증은 남성불임의 흔치 않은 원인이다. 저자들은 성선자극호르몬 특히 인간융 모성선자극호르몬 (Human chorioinc gonadotropin: hCG)/인간폐경성선자극호르몬 (Human ...
목 적: 저성선자극호르몬 성선저하증은 남성불임의 흔치 않은 원인이다. 저자들은 성선자극호르몬 특히 인간융 모성선자극호르몬 (Human chorioinc gonadotropin: hCG)/인간폐경성선자극호르몬 (Human menopausal gonadotropin: hMG) 치료가 정자형성 및 임신에 미치는 영향에 대해 알아보았다. 연구방법: 2001년 11월부터 2007년 3월까지 불임을 주소로 내원하여 저성선자극호르몬 성선저하증으로 진단되어 성선자극호르몬 (hCG/hMG) 치료를 받은 10명의 진료 기록을 후향적으로 분석하였다. 치료 후 임신 여부를 알아보았으며, 치료 전 고환의 용적에 따라 10 cc 미만인 군 (n=4)과 10 cc 이상인 군 (n=6)으로 나누어 치료 전후의 정액지표와 혈중 FSH, LH 및 testosterone 등의 호르몬 검사를 시행하여 비교하였다. 결 과: 10명의 환자 중 7명 (70%)에서 임신에 성공하였으며 치료 후 혈중 FSH, testosterone 수치가 의미있게 증가하였다. 고환 용적이 큰 군에서 치료 후 정액량, 정자수, 운동성 및 testosterone이 유의하게 증가하였다. 결 론: 불임을 주소로 온 환자에게 흔치는 않지만 면밀한 검사를 통해 저성선자극호르몬 성선저하증을 진단할 수 있어야 하며, hCG/hMG 병합요법은 자연임신 뿐만 아니라 최근의 보조생식술과 연계하여 충분히 성공적인 치료에 도달할 수 있다.
다국어 초록 (Multilingual Abstract)
Objective: Hypogonadotropic hypogonadism (HH) is an uncommon cause of male infertility. We investigated the outcome of gonadotropin therapy for restoring fertility and pregnancy outcomes in patients with HH. Methods: Medical charts of 10 infertile mal...
Objective: Hypogonadotropic hypogonadism (HH) is an uncommon cause of male infertility. We investigated the outcome of gonadotropin therapy for restoring fertility and pregnancy outcomes in patients with HH. Methods: Medical charts of 10 infertile male patients with HH treated with gonadotropin were reviewed. Initial testicular volume were estimated. Semen analysis parameters (semen volume, sperm counts, motility), serum leutenizing hormone (LH), follicle stimulating hormone (FSH), total testosterone were determined before and after human chorionic gonadotropin/human menopausal gonadotropin (hCG/hMG) treatment. Differences were analyzed statistically. Results: Of 10 patients, 7 (70%) succeed at pregnancy (nature pregnancy in 4). Semen analysis parameters, serum FSH, and testosterone were increased significantly after treatment. The population was stratified according to initial testicular volume into a small testis subset (testicular volume less than 10 cc in 4) and a large testis subset (testicular volume 10 cc or greater in 6). Semen analysis parameters and serum testosterone were increased significantly after treatment in large testis subset. Conclusion: Infertile men with HH initiate and maintain spermatogenesis with gonadotropin (hCG/hMG alone or combined) therapy, thus gonadotropin therapy is good choice in infertile men with HH.
참고문헌 (Reference)
1 D'Agta R, "Tesiticular responsiveness to chronic human chorionic gonadotropin administration in hypogonadotropic hypogonadism" 55 : 76-80, 1982
2 Büchter D, "Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases" 139 : 298-303, 1998
3 Russell LD, "Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow" 184 : 179-189, 1989
4 Miyagawa Y, "Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study" 173 : 2072-2075, 2005
5 Sigman M, "Male Infertility, in: Campbell's Urology 9th ed" Saunders 609-653, 2007
6 Bardin CW, "Male Hypogonadism, in: Reproductive Endocrinology, Physiology, Pathophysiology and Clinical Management. 2nd ed" Saunders 614-630, 1986
7 Rey RA, "Is infancy a quiescent period of testicular development? Histological, morphometric, and functional study of the seminiferous tubules of the cebus monkey from birth to the end of puberty" 76 : 1325-1331, 1993
8 Matsumoto AM, "Hormonal therapy of male hypogonadism" 23 : 857-875, 1994
9 Burris AS, "Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size" 66 : 1144-1151, 1988
10 Vicari E, "Gonadotropin replacement therapy in patients with hypogonadotropic hypogonadism" 438 : 454-458, 1984
1 D'Agta R, "Tesiticular responsiveness to chronic human chorionic gonadotropin administration in hypogonadotropic hypogonadism" 55 : 76-80, 1982
2 Büchter D, "Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases" 139 : 298-303, 1998
3 Russell LD, "Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow" 184 : 179-189, 1989
4 Miyagawa Y, "Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study" 173 : 2072-2075, 2005
5 Sigman M, "Male Infertility, in: Campbell's Urology 9th ed" Saunders 609-653, 2007
6 Bardin CW, "Male Hypogonadism, in: Reproductive Endocrinology, Physiology, Pathophysiology and Clinical Management. 2nd ed" Saunders 614-630, 1986
7 Rey RA, "Is infancy a quiescent period of testicular development? Histological, morphometric, and functional study of the seminiferous tubules of the cebus monkey from birth to the end of puberty" 76 : 1325-1331, 1993
8 Matsumoto AM, "Hormonal therapy of male hypogonadism" 23 : 857-875, 1994
9 Burris AS, "Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size" 66 : 1144-1151, 1988
10 Vicari E, "Gonadotropin replacement therapy in patients with hypogonadotropic hypogonadism" 438 : 454-458, 1984
11 Sigman M, "Endocrine evaluation of infertile men" 50 : 659-664, 1997
12 "American association of clinical endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update" 8 : 439-456, 2002
인간배아줄기세포로부터 간세포로의 유도 분화를 이용한 간질환 세포 치료의 최근 연구 동향
태반 내 Immortalization-upregulated Proteins-2 (IMUP-2) 발현
낮은 농도의 Hypoxanthine과 FSH가 미성숙난자의 체외성숙에 미치는 영향
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2024 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2021-01-01 | 평가 | 등재학술지 선정 (해외등재 학술지 평가) | |
2020-12-01 | 평가 | 등재후보로 하락 (해외등재 학술지 평가) | |
2012-01-05 | 학술지명변경 | 한글명 : 대한생식의학회지 -> Clinical and Experimental Reproductive Medicine외국어명 : The Korean Journal of Reproductive Medicine -> Clinical and Experimental Reproductive Medicine | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-08-28 | 학술지명변경 | 한글명 : 대한불임학회지 -> 대한생식의학회지외국어명 : The Korean Journal of Fertility and Sterility -> The Korean Journal of Reproductive Medicine | |
2007-08-28 | 학회명변경 | 한글명 : 대한불임학회 -> 대한생식의학회영문명 : Korean Society For Fertility And Sterility -> The Korean Society for Reproductive Medicine | |
2007-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2006-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2004-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0 | 0 | 0 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0 | 0 | 0 | 0 |