Fungal Keratitis Caused by Corynespora cassiicola, a Plant Pathogen

다국어 초록 (Multilingual Abstract)

A 74-year-old man presented with pain and progressively worsening vision from 20 days ago in the left eye. His ophthalmological history was significant for cataract extraction, scleromalacia, and three surgeries for pterygium removal in the left eye. Slit-lamp examination was remarkable for a 4.5×4.0 mm sized epithelial defect, with corneal stromal infiltration and melting and a surrounding feathery margin. Corneal scraping was performed, and culture of specimen demonstrated mold that grew on Sabouraud dextrose agar. The isolate was finally identified as Corynespora cassiicola based on DNA sequencing analysis of internal transcribed spacer (ITS) with maximum identity of 100%. The patient was treated successfully with intracameral amphotericin B injection and topical voriconazole and amphotericin B. To the best of our knowledge, this is the first reported case of mycotic keratitis caused by a plant pathogen, Corynespora cassiicola, in Korea.

참고문헌 (Reference)

1 Huang HK, "Subcutaneous infection caused by Corynespora cassiicola, a plant pathogen" 60 : 188-190, 2010

2 Yamada H, "Rare case of fungal keratitis caused by Corynespora cassiicola" 19 : 1167-1169, 2013

3 de Lamotte F, "Purification and characterization of cassiicolin, the toxin produced by Corynespora cassiicola, causal agent of the leaf fall disease of rubber tree" 849 : 357-362, 2007

4 Lv GX, "Phaeohyphomycosis caused by a plant pathogen, Corynespora cassiicola" 49 : 657-661, 2011

5 Qi YX, "Molecular and pathogenic variation identified among isolates of Corynespora cassiicola" 41 : 145-151, 2009

6 Revankar SG, "Melanized fungi in human disease" 23 : 884-928, 2010

7 Shrestha SK, "Genome sequences and SNP analyses of Corynespora cassiicola from cotton and soybean in the southeastern United States reveal limited diversity" 12 : e0184908-, 2017

8 Lee HB, "First report of stem blight on perilla (Perilla frutescens) caused by Corynespora cassiicola in Korea" 93 : 550-, 2009

9 Mahgoub E, "Corynespora cassiicola, a new agent of maduromycetoma" 72 : 218-221, 1969

10 de Hoog GS, "Atlas of Clinical Fungi" Centraalbureau voor Schimmelcultures 596-597, 2000