Fabrication of hollow manganese oxide nanoparticles for the MRI application and synthesis of Fe3O4/Pd and FePd nanoparticles through the solid-state reaction confined within a silica nanosphere

다국어 초록 (Multilingual Abstract)

Hollow nanoparticles with interior void spaces are attractive candidates for advanced MRI contrast agents owing to their large water-accessible surface area, which is able to carry high payloads of MR-active magnetic centers, and the ability of the interior void space to take up large amounts of drug molecules. In this context, hollow manganese oxide nanoparticles were synthesized by selectively carving away the core from nanoparticle having MnO core coated by Mn3O4 shell. The hollow nanoparticles showed the greatly enhanced relaxivities and drug loading capacity, comparing with those having solid interior. Their efficient cellular uptake allowing for the delivery of anticancer reagents was also examined, demonstrating their potential as bifunctional medical system combining diagnostic imaging and drug treatment.

다국어 초록 (Multilingual Abstract)

Due to their potential to integrate different functionalities in individual nanocrystals, the hybrid nanocrystals have been receiving significant current attention. In this work, we synthesized anisotropically phase-segregated Fe3O4/PdO heterodimers nanocrystals during the thermal annealing of silica nanospheres encapsulating Fe3O4 nanocrystals and Pd2+ complexes. When the nanospheres containing the heterodimer were annealed under reductive environment, it was revealed that the nanostructure were converted into either Fe3O4/Pd heterodimers or FePd alloy nanocrystals depending on the annealing temperature. In this presentation, we will report the synthesis and controllable transformation of Fe3O4/PdO heterodimer in silica nanosphere.

목차 (Table of Contents)

• [ Part 1 ]
• 1. Introduction 1
• 2. Experimental section 3
• 1) General consideration 3
• 2) Particle synthesis 3
• (1) Synthesis of manganese oxide nanoparticles
• (2) Synthesis of water dispersible manganese oxide nanoparticles
• (3) Synthesis of hollow manganese oxide nanoparticles
• 3) Measuring MRI relaxation properties 3
• 4) Investigation of drug loading capacity and release profile 5
• 5) Investigation of cell labeling and drug delivery with HMON 7
• (1) Cell culture
• (2) Confocal laser scanning microscopy
• (3) Cytotoxicity evaluation
• (4) In vitro MRI of cells
• 6) Mouse in vivo MRI 8
• 3. Result and conclusion 10
• 4. Reference 18
• Abstract 21
• [ Part 2 ]
• 1. Introduction 23
• 2. Experimental section 25
• 1) General consideration 25
• 2) Particle synthesis 25
• (1) Synthesis of Iron oxide nanoparticles
• (2) Synthesis of Fe3O4/Pd2+@SiO2
• (3) Fe3O4/Pd2+@SiO2 thermal annealings at air and H2 atmosphere
• 3. Result and conclusion 28
• 4. Reference 35
• Abstract 37