Preventive effect of Polysaccharide of Larimichthys Crocea Swimming Bladder on Activated Carbon- Induced Constipation in Mice

다국어 초록 (Multilingual Abstract)

Effects of polysaccharide of Larimichthys croceaswimming bladder (PLCSB) on activated carbon-induced constipationin ICR mice were investigated. ICR mice were subjected to oraladministration with lactic acid bacteria for 9 days. Body weight,diet and drinking intake, defecation status, gastrointestinal transit,and defecation time, as well as motilin (MTL), gastrin (Gas),endothelin (ET), somatostatin (SS), acetylcholinesterase (AChE),substance P (SP), and vasoactive intestinal peptide (VIP) levels inserum were used to evaluate the preventive effects of PLCSB onconstipation. Bisacodyl, a laxative drug, was used as a positivecontrol. The time to the first black stool defecation for normal,control, bisacodyl-treated (100 mg/kg), 50 and 100 mg/kg PLCSBtreatedmice were 88, 202, 126, 155, and 135 min, respectively.
Following the consumption of oral administration of 50 and 100mg/kg PLCSB or bisacodyl (100 mg/kg), the gastrointestinaltransit was reduced to 62.6, 78.3, and 90.2%, respectively. Theserum levels of MTL, Gas, ET, AChE, SP, and VIP weresignificantly increased, and the serum levels of SS were reducedin the mice treated with PLCSB compared with those in theuntreated control mice (p <0.05). These results demonstrate thatPLCSB has preventive effects on mouse constipation and highconcentration of that demonstrated the better functional activity.

참고문헌 (Reference)

1 Milner P, "Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease" 99 : 666-675, 1990

2 Furchgott RF, "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine" 288 : 373-376, 1980

3 Yan C, "Study on extraction of Lycium barbarum polysaccharides by different methods and their antioxidant effects in vitro" 29 : 183-187, 2008

4 Dolk A, "Slow transit chronic constipation (Arbuthnot Lane’s disease). An immunohistochemical study of neuropeptide-containing nerves in resected specimens from the large bowel" 5 : 181-187, 1990

5 Lubowski DZ, "Results of colectomy for severe slow transit constipation" 39 : 23-29, 1996

6 Feighner SD, "Receptor for motilin identified in the human gastrointestinal system" 284 : 2184-2188, 1999

7 Walia R, "Recent advances in chronic constipation" 21 : 661-666, 2009

8 Qian Y, "Preventive effect of resistant starch on activated carbon-induced constipation in mice" 6 : 228-232, 2013

9 Preston DM, "Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders" 26 : 1059-1064, 1985

10 Emmanuel AV, "Pharmacological management of constipation" 21 : 41-54, 2009

11 Sjölund K, "Motilin in chronic idiopathic constipation" 21 : 914-918, 1996

12 Li C, "Molecular and expression characterizations of interleukin-8 gene in large yellow croaker (Larimichthys crocea)" 34 : 799-809, 2013

13 Ueki A, "Life style risks of Parkinson's disease: Association between decreased water intake and constipation" 251 : 18-23, 2004

14 Chen LH, "Increased preventive effect on colon carcinogenesis by use of resistant starch (rs3) as the carrier for polysaccharide of Larimichthys crocea swimming bladder" 15 : 817-829, 2014

15 Battish R, "Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase" 278 : 148-155, 2000

16 Miller SM, "Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase" 13 : 121-131, 2001

17 Jian JC, "Effects of traditional Chinese medicine on nonspecific immunity and disease resistance of large yellow croaker, Pseudosciaena crocea (Richardson)" 218 : 1-9, 2003

18 Silkoff P, "Effect of substance P on rat gastrointestinal transit" 33 : 74-77, 1998

19 Soudah HC, "Effect of octreotide on intestinal motility and bacterial overgrowth in scleroderma" 325 : 1461-1467, 1991

20 Shan JJ, "Effect of an antidiabetic polysaccharide from Inula japonica on constipation in normal and two models of experimental constipated mice" 24 : 1734-1738, 2010

21 Farrugia G, "Distribution of heme oxygenase and effects of active carbon monoxide in canine jejunum" 274 : 350-358, 1998

22 Tzavella K, "Decreased substance P levels in rectal biopsies from patients with slow transit constipation" 8 : 1207-1211, 1996

23 El-Salhy M, "Colonic neuroendocrine peptide levels in patients with chronic idiopathic slow transit constipation" 103 : 223-230, 1998

24 Xue L, "Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes" 97 : 1851-1855, 2000

25 Farrugia G, "A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract" 100 : 8567-8570, 2003

26 Wexner SD, "A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)" 63 : 894-909, 2006