진저요법이 화학요법을 받는 암 환자의 오심과 구토에 미치는 효과 : 체계적 고찰 및 메타분석

국문 초록 (Abstract)

본 연구는 체계적 고찰과 메타분석을 이용하여 진저요법이 화학요법을 받는 암 환자의 오심과 구토에 미치는 효과를 파악하기 위하여 수행되었다. 문헌검색을 위해 CINAHL, PubMed, Cochrane, EMBASE, Web of Science, Google Scholar 데이터베이스를 이용하였으며, 2009년부터 2018년까지 출간된 연구 396편 중 선정과 배제기준에 따라 최종 선정된 RCT 연구 8편에 대한 질 평가는 Revised Cochrane risk-of-bias tool 2(RoB 2)를 이용하였다. 메타분석은 RevMan 5.4 프로그램을 사용하였으며 오심과 구토의 발생빈도는 평균승산비(Odds Ratio, OR), 강도는 표준화된 평균 차이(Standardized Mean Difference, SMD)를 산출하였다. 진저요법이 오심에 미치는 효과로 발생빈도 OR= 0.92[0.65, 1.30], 강도 SMD= -0.12[-0.59, 0.35]로 통계적으로 유의하지 않았으며 하위집단 분석 결과 급성기와 지연기 모두 진저요법의 효과가 유의하지 않은 것으로 나타났다. 진저요법이 구토에 미치는 효과로 발생빈도 OR=0.89[0.62, 1.27], 강도 SMD= -0.45[-1.04, 0.13]로 통계적으로 유의하지 않았으며 하위집단 분석에서도 급성기와 지연기 모두 진저요법의 효과가 유의하지 않은 것으로 나타났다. 연구의 질 평가에 따라 민감성 분석 결과 고위험 연구의 효과 크기는 실제 효과에 비해 과장되었을 가능성이 있는 것으로 나타났다. 진저요법이 화학요법을 받는 암 환자의 오심과 구토 완화에 유의하지 않은 것으로 나타났으나 포함된 연구의 수가 충분치 않아 본 연구를 일반화하기에는 한계가 있어 추후 연구가 필요할 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

This study was undertaken to assess effects of ginger on nausea and vomiting in cancer patients receiving chemotherapy, through systematic review and meta-analysis. CINAHL, PubMed, Cochrane, EMBASE, Web of Science, and Google Scholar databases were explored. From a total of 396 studies, 8 Randomized Controlled trials during the period 2009 to 2018 were selected and qualitatively evaluated using the Revised Cochrane Risk-of-Bias tool 2. Assessment of the frequency and intensity of nausea and vomiting was achieved by estimating the Odds Ratio (OR) and Standardized Mean Difference (SMD), respectively, using the RevMan 5.4. No significant effect of ginger was observed for nausea (OR=0.92 [0.65, 1.30] and SMD=-0.12 [-0.59, 0.35]), and subgroup analyses also revealed no significant effect on both the frequency and intensity in acute phase and delayed phase. Results also show that ginger has no significant effect on vomiting (OR=0.89 [0.62, 1.27] and SMD=-0.45 [-1.04, 0.13]), neither was any significant effect determined in both the acute and delayed phase through subgroup analyses. Sensitivity analysis revealed that the effect size of high-risk studies could have resulted in overestimation. Although the current study detected no significant effect of ginger on nausea and vomiting, the results cannot be generalized due to the limited number of studies included, which needs to be addressed in the future.

목차 (Table of Contents)

• 요약
• Abstract
• 1. 서론
• 2. 연구방법
• 3. 연구결과
• 4. 논의
• 5. 결론
• References

참고문헌 (Reference)

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