Beans and Diabetes: Phaseolus vulgaris Preparations as Antihyperglycemic Agents

다국어 초록 (Multilingual Abstract)

Bean pods (Phaseolus vulgaris) are among the most widely used traditional remedies against diabetes mellitus. Historical knowledge is summarized and compared to recent study results. Reports dating from the first half of the 20th century as well as recent publications show contradictory results. It seems that Phaseolus preparations should not be considered the first choice in phytopharmaceutical treatment of diabetes or lead structure research. To be effective, fairly high doses of aqueous extracts need to be given. Because of their fiber content and an α-amylase inhibitory effect, beans might be more useful as food components in preventing or ameliorating type 2 diabetes.

참고문헌 (Reference)

1 Lapp FW, "Wert der Insulin- und Kohlehydratersatzmittel in der Diabetestherapie" 78 : 195-199, 1937

2 Eisler M., "U¨ ber insulinartige Stoffe aus Bohnen und deren Wirkung auf den Kohlehydratstoffwechsel" 148 : 566-572, 1928

3 Bertram F., "U¨ ber die medikamento¨se Behandlung des Diabetes mellitus (mit Ausschluss der parenteralen Insulintherapie)" 7 : 1208-1214, 1928

4 Gebhardt F., "U¨ ber Phaseolan" 70 : 397-402, 1930

5 Geßner O., "Ueber die blutzuckersenkende Wirkung von Phaseoluspra¨paraten (Decoctum Phaseoli sine semine und Phaseolanum fluidum ‘‘Tosse’’)" 75 : 853-855, 1928

6 Kaufmann M., "Ueber die Einwirkung von Medicamenten auf die Glukosurie der Diabetiker" 48 : 260-289, 1908

7 Bailey CJ, "Traditional plant medicines as treatments for diabetes" 12 : 553-564, 1989

8 Gohr H., "Tierexperimentelle Untersuchungen u¨ber die blutzuckersenkende Wirkung des vinum fluidum ‘‘Tosse’’ mit BEANS AND DIABETES 253 besonderer Beru¨cksichtigung der Organanalyse" 143 : 269-282, 1929

9 Labbe´ H., "The vegetable insulinoids and their therapeutic indications" 34 : 141-144, 1936

10 Cerovic´ A., "The dry plant extract of common bean seed (Phaseoli vulgari pericarpium) does not have an affect on postprandial glycemia in healthy human subject" 6 (6): 28-33, 2006

11 Bliss M., "The Discovery of Insulin" Faber and Faber 183-, 1982

12 Helmsta¨dter A., "Syzygium cumini (L.) Skeels (Myrtaceae) against diabetes—125 years of research" 63 : 91-101, 2008

13 Rau O., "Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor" 61 : 952-956, 2006

14 Leelavinothan Pari, "Protective Role of Phaseolus vulgaris on Changes in the Fatty Acid Composition in Experimental Diabete" 한국식품영양과학회 7 (7): 204-209, 2004

15 Best CH, "Possible sources of insulin" 3 : 177-179, 1923

16 Xavier-Filho J., "Plant insulin or glucokinin: a conflicting issue" 15 : 67-78, 2003

17 Melzig MF, "Pflanzliche alpha-Amylasehemmer—eine Mo¨glichkeit zur Phytotherapie bei Diabetes mellitus Typ II?" 157 : 320-324, 2007

18 Ratsimamanga RA, "Mischungen ausgehend von Eugenia jambolana Lamarck Samen, Herstellung und Verwendung solcher Mischungen sowie einiger Inhaltsstoffe als Medikamente, EU Patent 0879 058 B1 (DE 697 05 108 T2)"

19 Bailey CJ, "Metformin: its botanical background" 21 : 115-117, 2004

20 Atta-Ur-Rahman, "Medicinal plants with hypoglycemic activity" 26 : 1-55, 1989

21 Li A., "J.B. Collip and the Development of Medical Research in Canada" Extracts and Enterprise 38-40, 2003

22 Kaufmann E., "Insulinersatzmittel. V. Mitteilung. U¨ ber blutzuckersenkende Stoffe in Cerealien und Leguminosen" 62 : 147-153, 1928

23 Kaufmann E., "Insulinartige Pflanzenextrakte. III. Mitteilung. Weiteres u¨ber die Wirkung des Bohnenschalentees (Phaseolin)" 60 : 285-288, 1928

24 Kaufmann E., "Insulinartige Pflanzenextrakte. II. Mitteilung. Die Behandlung des Diabetes mit Bohnenschalentee" 55 : 1-12, 1927

25 Neef H., "Hypoglycemic activity of selected European plants" 9 : 45-48, 1995

26 K. Shetty, "Health Benefits of Traditional Corn, Beans, and Pumpkin: In Vitro Studies for Hyperglycemia and Hypertension Management" 한국식품영양과학회 10 (10): 266-275, 2007

27 Hadden DR, "Goats’s rue—French lilac—Italian fitch—Spanish sainfoin: Galea officinalis and metformin: the Edinburgh connection" 35 : 258-260, 2005

28 Collip JB, "Glucokinin. A new hormone present in plant tissue. Preliminary paper" 56 : 513-543, 1923

29 Hartleb HO, "Experimentelle und klinische Untersuchungen zur Frage der peroralen Diabetesbehandlung mit insulina¨hnlichen pflanzlichen Stoffen (Phaseolan)" 79 : 1795-1797, 1932

30 Roma´n-Ramos R., "Experimental study of the hypoglycemic effect of some edible plants" 22 : 87-93, 1991

31 Elllingwood F., "Ellingwood’s Therapeutist, Vol. 2"

32 Pari L., "Effect of an aqueous extract of Phaseolus vulgaris on plasma insulin and hepatic key enzymes of glucose metabolism in experimental diabetes" 58 : 916-919, 2003

33 Otten JH, "Die Geschichte der oralen Diabetestherapie" University of Freiburg 1966

34 Lewis JJ, "Diabetes and the insulin-administration problem" 29 : 75-89, 1949

35 Venn BJ, "Cereal grains, legumes and diabetes" 58 : 1443-1446, 2004

36 Venkateswaran S., "Antioxidant effect of Phaseolus vulgaris in streptozotocin-induced diabetic rats" 11 : 206-209, 2002

37 Roma´n-Ramos R., "Antihyperglycemic effect of some edible plants" 48 : 25-32, 1995

38 Helmsta¨dter A., "Antidiabetic drugs used in Europe prior to the discovery of insulin" 62 : 717-720, 2007

39 Tan GY, "Antidiabetic components in vegetables and legumes" 13 : 1189-1194, 2008