Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects

다국어 초록 (Multilingual Abstract)

Balanophora laxiflora Hemsl. (Balanophoraceae) is a traditional medicinal plant with a diverse array of biological activities. In our exploration of new bioactive constituents from B. laxiflora, we isolated five compounds, including a new lignan, balanophorone (5), and four known phenolic compounds (1–4). The chemical structures of these compounds were determined by extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS, and CD. In addition, we evaluated the effects of each of the isolates (1–5) on the messenger RNA expression levels of tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells. Compound 2 showed significant inhibition of LPS-induced COX-2 and TNF-α expression in RAW 264.7 macrophages, while compound 4 showed moderate cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells, with IC50 values of 18.3 and 30.7 μM, respectively. No significant effects on the viability of normal mammary epithelial cells were observed.

참고문헌 (Reference)

1 Bui, H. T., 14 : 1-6, 2019

2 Jung, K. Y., 61 : 808-811, 1998

3 Tran, D. D., 55 : 48-51, 2017

4 Wang, X., 6 : 79-, 2012

5 Ho, S. T., 122 : 584-588, 2010

6 Ho, S. T., 2012 : 1-7, 2012

7 Quang, D. N., 32 : 767-772, 2018

8 Chiou, W. F., 19 : 502-508, 2011

9 Liao, S. G., 89 : 73-80, 2006

10 Mosmann, T., 65 : 55-63, 1983

11 Pham, D. V., 12 : 613-, 2020

12 Masi, M., 114 : 37-39, 2017

13 Stange, R. R., 52 : 41-43, 1999

14 Do, T. L., "Vietnamese medicinal plants and herbs" Medical publisher 114-, 2014

15 Nguyen, M. K., "List of medicinal plants in Vietnam" Science and Technics Publishing House 628-, 2016

16 장대식, "Flavonoids and Aromatic Compounds from the Rhizomes of Zingiber zerumbet" 대한약학회 27 (27): 386-389, 2004