가스 크로마토그래피 분석과 세포독성에 의한 계피 정유의 품질평가 = Quality Evaluation of the Chinnamon Essential Oils Based on Gas Chromatographic Analysis and Cytotoxicity

다국어 초록 (Multilingual Abstract)

To evaluate the quality of the crude drugs using three kinds of Cinnamomum Cortex (CC), Vietnamese CC (VCC,
the stem bark of Cinnamomum obtusifolium), periderm-peeled Chinese CC (PPCC, periderm-peeled stem bark of C. cassia),
Chinese CC (CCC, stem bark of C. cassia) and a Cinnamomi Ramulus (CR, the twig of C. cassia), the four essential oils were
prepared by steam distillation method. Cinnamaldehdye (CNA) and an unknown substance tentatively named hydroxycinnamaldehdye
(HCNA) were detected in the four essential oils by gas chromatography-mass spectrometry, the contents of
which are significantly different one another. Vietnamese CC had the highest content of HCNA whereas CR had the highest
CNA content and the lowest HCNA. Vietnamese CC exhibited the greatest cytotoxic activity against the cancer cell lines, A549,
HepG-2, HL-60, P-388, U-937, and KB and CR the lowest cytotoxicity. Contents of CNA and HCNA in CCC and PPCC are
positioned between VCC and CR. These results suggest that measurement of HCNA and cytotoxicity may determine the quality
of CC and CR.