한국인 기관지천식환자에 있어서의 HLA 항원분포에 관한 연구 = 한국인 기관지천식환자에 있어서의 HLA 항원분포에 관한 연구

다국어 초록 (Multilingual Abstract)

It is becoming increasingly understood that more than one genetic locus is involved in determining familial predisposition to asthma. One of such loci may be within the HLA system since a number of studies have suggested an association between HLA antigens and asthma. In the present study, 50 cases of bronchial asthmatics were selected. HLA types, allergen skin test and serum IgE levels were analyzed and the data were compared with those of control group. The results were as follows: l. In all bronchial asthmatics, HLA-Cw3 was significantly increased and HLA-A10 was significantly decreased with respect to controls (P < 0.01, P < 0.05). 2. In patients with negative skin test, HLA-A9 was significantly increased with respect to controls (P < 0.025). 3. In patients with positive skin test, HLA-Cw3 was significantly decreased with respect to controls (P < 0.005). 4. In patients with positive skin test for the D. farinae, HLA-A3 and HLA-Cw3 were significantly increased with respect to controls (P < 0.02, P < 0.05). 5. No significant differences of HLA antigen frequencies were present in patie nts with positive skin test for the antigens except the D. farinae. 6. In patients with high serum IgE levels gE > 1000 IU/ml), HLA-Al and HLA-B12 were significantly increased with respect to controls (P < 0.05, P < 0.025). 7. In patients with low serum IgE levels ggE < 1000 IU/ml), HLA-Cw3 was significantly increased and HLA-A10 was significantly decreased with respect to controls (P < 0.05, P < 0.05).