동종골수이식 중 발생한 Vancomycin 내성 Enterococci (VRE) 감염에 의한 패혈증 1례 = Vancomycin-Resistant Enterococcal Sepsis in a Allogeneic Bone Marrow Transplantation Recipient

국문 초록 (Abstract)

최근 항생제의 남용에 의한 항생제에 대한 내성균주가 증가하고 있다. 특히 vancomycin 내성 장구균이 중환자실 환자 등에서 급속히 증가하고 있으나, 내성균에 대한 확실한 치료방법이 없어 내성균주의 전파에 주의하여야 한다. 저자들은 국내에서 골수이식과 관련된 VRE 패혈증에 의한 사망한 1예를 경험하여 문헌고찰과 함께 보고하는 바이다.

다국어 초록 (Multilingual Abstract)

Enterococci are inhabitant of the intestinal tract of human. Vancomycin-resistant enterococci (VRE) were first recognized in the min-1980s. VRE infection have been increasingly reported in immunosuppressed patients over the past decade and have became one of major nososcomial pathogens. The mortality rate for the patients with VRE bacteremia are extremely high because the optimal therapy for these infection is unknown. Moreover VRE have a potential to transfer their resistance genes to pathogenic gram-positive bacteria. We report a case of vancomycin-resistant E. faecium sepsis in a patient undergoing allogeneic BMT. She had multiple cytotoxic chemotherapies, and received prolonged course of multiple broad-spectrum antibiotics including vancomycin during complicated transplantation course.