家兎에 있어서 Pivampicillin. Hcl과 Ampicillin의 血中濃度 比較硏究 = Studies on Blood Concentration of Pivampicillin as Compared with Ampicillin by Oral Administration in Rabbit

다국어 초록 (Multilingual Abstract)

Although D(-)-α-aminobenzyl penicillin(ampicillin) is relatively stable to acid it is absorbed inefficiently by the oral route as indicated, e.g., by the fact that much higher blood levels and urinary recovery are attained after parenteral than after oral administratration.
Of a series of acyloxymethyl esters of ampicillin which are more completely absorbed than the parent compound, the hydrochloride salt of pivampicillin was selected for extended studies. Comparative studies of pivampicillin and smpicillin in 20 healthy rabbits revealed that pivampicillin is better absorbed from the gastro-intestinal tract than ampicillin, as reflected in considerably higher peak ampicillin concentration in blood.