알쯔하이머 병의 분자 유전학 = Molecular Genetics of Alzheimer's Disease

다국어 초록 (Multilingual Abstract)

The sequencing of the amino acids in the β-amyloid and the cloning of the amyloid precursor protein(APP) gene were the breakthrough event in the molecular biologic researches about the Alzheimer’is disease. After then, the mutations in the APP gene, presenilin 1 gene and presenilin 2 *gene associated with the familial Alzheimer’s disease(FAD) were found. Also, the roles of APOLEε 4 as a risk allele and APOLE ε2 as a protective allele in late onset AD, were demonstrated. All of the mutations causing FAD were known to function through a common final pathway which involves the increase on fibrillogenic form af Aβ. The APOLE allele seems to influence the production, distribution and clearance of Aβ. Such expansion in the understanding of AD molecular genetics give hopes to the development of novel therapeutic modalities.