혈청학적으로 진단된 Leptospirosis 의 임상상과 혈청 항체역가의 변동 = Clinical Features of Serologically Proven Leptospirosis in Korea and Changes in Leptospiral Agglutinin Titer

다국어 초록 (Multilingual Abstract)

52 cases of human leptospirosis occurring in Yeoju area during the period August-November, 1985 were examined. The clinical illness was characterized by the abrupt onest of fever, chills, and myalgia; headache, gastrointestinal complaints, cough and hemoptysis were not uncommon. The most characteristic physical findngs were abdominal tenderness, CVA tenderness, conjunctivitis, and abnormal chest auscultation. Clinical patterns by involved organ were variable. Hepatitis was present in 50%, pneumonitis with or without pulmonary hemorrhage in 57.7%, and nephritis in 53.8%. Jaundice, central nervous system involvement and renal failure were uncommon than in other series. Leptospirosis in our study was an acute, self-limited febrile illness of short duration, There were two deaths due to fulminant pulmonary hemorrhage in the early stage. Seven patients had no clinical finding other than fever and myalgia; without serological surveillance, these illness would have remained idiopathic. The apperance of agglutinating antibody was detected from one week of illness in 65.7% of patients and frequently coincided with the initial defeverscence. Rising agglutinating titers reached their peak between one and two week after onset of illness and persisted in high titer for five months at least.