Thiourea를 투여한 백서에서 Surfactant-Associated Protein A, B, C의 유전자 발현 동태 = Gene Expression of Surfactant Associated Protein A, B, and C in Thiourea Treated Rats

다국어 초록 (Multilingual Abstract)

Thiourea produces pulmonary edema secondary to permeability changes in the lung microvasculature.
Since thiourea induced lung damage is similar or identical to changes of adult respiratory distress syndrome and abnormalities in surfactant function have been described in adult respiratory distress syndrome, the author investigated the effedcts of thiourea on the regulation of surfactant-associated protein A,B and C mRNA accumulation. Adcult rats were treated with 3.5mg/kg doses of thiourea intraperitoneally and sacrificed at different time points. Surfactant associated proteins mRNAs were measured by filter hybridization. Although the abscence of alterations in lung wet to dry ratios. lung injury by thiourea decreased 22.7% of normal for SP-A mRNA (P<0.001) and 22.8 of normal for SP-C mRNA(P<0.025) significantly at each 6 hour. Also there was decrease in SP-B mRNA.
These findings represent a marked ingibitory effects of thiourea on surfactant-associated proteins expression in vivo. This supports, in turn, inhibitory effects of thiourea related to pathogenesis of adult respiratory distress syndrome.