Role of α2 Receptors in Quercetin-Induced Behavioral Despair in Mice

다국어 초록 (Multilingual Abstract)

Depression is a well-defined illness that afflicts a large population worldwide. Various biochemical theorieshave been described; however, the pathophysiology of depression is still poorly understood. The present study explores therole of a natural flavonoid, quercetin, in the forced swimming model of depression and its interaction with presynaptic .2adrenoceptors. Quercetin induced a significant behavioral despair, which was abrogated with pretreatment with yohimbine,an .2 adrenoceptor antagonist, and imipramine, a tricyclic antidepressant. The results of the study support the contention thatquercetin utilizes presynaptic .2 adrenoceptors in eliciting its depressant activity in mice.

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