Changes of Gastrointestinal Chromogranin-Immunoreactive Cells after Implantation of Colon-26 Murine Carcinoma Cells in BALB/c Mouse

다국어 초록 (Multilingual Abstract)

The changes on the regional distribution and frequency of chromogranin-immunoreactive (CG-IR) cells in gastrointestinal (GI) tract of BALB/c mouse after implantation of murine carcinoma cells, colon-26 were studied by immunohistochemical methods. The experimental animals were divided into two groups; non¬implanted (Sham) and colon-26 (CT-26) cell implanted (Colon-26) groups. Samples were collected from each part of GI tract (fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum) at 28th days after subcutaneously implantation of CT-26 cells (1×10⁵ cell/mouse). CG-IR cells were distributed throughout the whole GI tract except for the rectum in Sham with various frequencies. However, they were restricted to the fundus, pylorus, duodenum and jejunum of Colon-26. A significantly (p＜0.01) decrease of CG-IR cells was detected in Colon-26 compared to that of Sham in both fundus and pylorus, but similar cell frequencies were detected in the duodenum and jejunum, respectively. In conclusion, the CG is generally known that it is one of the endocrine markers. Therefore, the abnormality in density of GI endocrine cells detected in the mouse implanted with CT-26 cells may contribute to the development of GI symptoms such as anorexia and indigestion, frequently encountered in patients with cancer.

목차 (Table of Contents)

• Materials and Methods
• Results
• Discussion
• References