고강도 지구성 운동이 골격근내 p53, p-FoxO1 및 MuRF1 단백질의 발현에 미치는 영향 = The expression of p53, pFoxO-1 and MuRF1 protein in skeletal muscle during intensity endurance training

국문 초록 (Abstract)

강윤석, 김정하, 유성경, 박대령, 김재철. 고강도 지구성 운동이 골격근내 p53, p-FoxO1 및 MuRF1 단백질의 발현에 미치는 영향. 운동과학. 제20권 제4호. 379-388. 2011. 고강도 지구력 운동(26 m/min, 10°, 15 min, 30 min, 45 min, 60 min, 90 min)을 하는 동안 쥐의 골격근내 p53, p-FoxO1 및 MuRF1 단백질의 발현을 규명하는데 연구의 목적이 있으며, 골격근내 단백질 발현은 western blotting 방법을 통해 분석하였다. p53 단백질의 발현의 경우 적색 및 백색 비복근 모두 운동 45분에 현저하게 증가하였다. p-FoxO1 단백질 발현의 경우적색 비복근에서는 운동 30분~45분의 증가한 반면에 백색 비복근에서는 운동 15분과 60분에서 높게 증가하는 것으로 나타났다. MuRF1 단백질 발현의 경우 운동 15분과 45분에서 증가한 반면에 백색 비복근에서는 운동 15분에서 높게 증가하는 것으로 나타났다. 이러한 결과는 고강도 지구력 운동을 하는 동안 p53, p-FoxO1 및 MuRF1 단백질이 근세포 손상에 대한 항상성을 유지하는데 중요하게 작용하고 있는 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

Kang, Y. S., Kim, J. H., Yu, S. K., Park, D. R., Kim, J. C. The expression of p53, pFoxO-1 and MuRF1 protein in skeletal muscle during intensity endurance training. Exercise Science. 20(4): 379-388, 2011. The aim of this study was to investigate the expression of p53, p-FOXO-1, and MuRF-1 protein in the skeletal muscle of Sprague-Dawley rats during intensity endurance exercise (26 m/min, 10°, 15 min, 30 min, 45 min, 60 min, 90 min). The expression of p53, p-FoxO1, and MuRF1 protein in skeletal muscle by western blotting. The expression of p53, p-FoxO1, and MuRF1 protein significantly were increased at 15min to 30 min during intensity endurance exercise and then gradually returned to bofore exercise level. These finding suggest that p53, p-FoxO1, and MuRF1 protein plays a role in the maintennance of homeostasis in skeletal muscle during intensity endurance exercise.

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