행인에서 추출한 Amygdalin이 좌골신경 단열로 신경이 손상된 쥐의 기능회복 및 중심회백질의 c-Fos 발현에 미치는 영향 = Effect of Amygdalin on the Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Crushed Sciatic Nerve Injury in Rats

국문 초록 (Abstract)

배경 : 말초 신경 손상은 임상에서 자주 발생하는 질환으로 통증 조절계에 영향을 주어 만성 통증을 유발하고, 연관 부위에 운동 기능 장애를 남기는 질환이다. 목적 : 본 연구의 목적은 좌골 신경 손상으로 유발된 만성 통증과 운동기능 저하에 있어 Amygdalin의 통증 감소 및 기능 회복 효과에 대 하여 알아보고자 함이다. 방법 : 좌골 신경에 손상을 입힌 쥐에 행인에서 추출된 Amygdalin을 복강내에 투입하여, 보행 분석과 면역조직화학을 활용한 vlPAG내 c-Fos 발현을 측정하여 통증 감소 및 기능 회복 정도를 판별하였다. 결과 : 복강 내에 행인에서 추출된 Amygdalin을 투입을 한 쥐는 보행분석과 면역조직화학을 활용한 vlPAG내 c-Fos 발현 정도에서 통증 감 소 및 기능 회복에 있어 유의성 있는 변화를 보였다. 결론 : Amygdalin은 말초 신경 손상에 의한 질환에 있어 통증 조절 및 운동 기능 회복에 뚜렷한 효과가 있는 것으로 생각된다.

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