A Natural Marine Compound Extracted from the Ark Shell, Scapharca Subcrenata, Inhibits in Vivo and in Vitro Angiogenesis

다국어 초록 (Multilingual Abstract)

Angiogenesis is an integral process in the growth and spread of solid tumors, and anti-angiogenesis therapy is one of the most promising therapeutic strategies for the treatment of cancer. In this study, we show that a natural marine compound extracted from ark shell, Scapharca subcrenata, has anti-angiogenic activities. Ark shell extract inhibited the proliferation, migration, invasion and tube formation of human umbilical vein endothelial cells (HUVECs), and suppressed the release of matrix metalloproteinase-2 (MMP-2) by HUVECs. In addition, ark shell extract also inhibited in vivo angiogenesis in a mouse Matrigel-plug assay. Taken together, these results suggest that ark shell extract acts as a novel angiogenesis inhibitor and could be further developed as an anticancer agent. (Cancer Prev Res 13, 47-53, 2008)

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