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KISSThree polyacetylenes, one novel and two known. were isolated from the root of Angelica tenuissima. U ing <sup>1</sup>H- and<sup>13</sup>C_NMR, COSY. HMBC, and HMQC, their truciure were found to be (3R,8S)-heptadeca-1-en-4.6-diy...
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RISS 인기검색어
Anti-Inflammatory Activity of a Novel Acetylene Isolated from the Roots of Angelica tenuissima NAKAI = Anti-Inflammatory Activity of a Novel Acetylene Isolated from the Roots of Angelica tenuissima NAKAI
한글로보기https://www.riss.kr/link?id=A102131949
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2016
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작성언어
Korean
-
주제어
Angelica tenuissima ; Polyacetylenes ; No ; INOS ; COX-2
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자료형태
학술저널
-
수록면
4-4(1쪽)
- 제공처
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중단사유
※ KISS의 원문 서비스 중단에 따라, 학술지명을 클릭하여 [복사/대출] 서비스를 이용해 주시기 바랍니다.
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다국어 초록 (Multilingual Abstract)
Three polyacetylenes, one novel and two known. were isolated from the root of Angelica tenuissima. U ing <sup>1</sup>H- and<sup>13</sup>C_NMR, COSY. HMBC, and HMQC, their truciure were found to be (3R,8S)-heptadeca-1-en-4.6-diyne-3,8-diol (1), falcarindiol (2). and oplopandiol (3). Absolute configuration of compound 1 were established using Mosher`s esterification. In addition. the polyacetylenes (1 - 3) were evaluated for their anti-inflammatory activity. Compounds 1 and 3 showed potent inhibitory activity against lipopolysaccharide-induced nitric oxide (N0) production in RAW267.7 macrophage cell with IC<sub>50</sub> value of 4.31 and 5.06 μM. respectively. Compound 1. strongly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in a concentration-dependent manner.
Three polyacetylenes, one novel and two known. were isolated from the root of Angelica tenuissima. U ing <sup>1</sup>H- and<sup>13</sup>C_NMR, COSY. HMBC, and HMQC, their truciure were found to be (3R,8S)-heptadeca-1-en-4.6-diyne-3,8-diol (1), falcarindiol (2). and oplopandiol (3). Absolute configuration of compound 1 were established using Mosher`s esterification. In addition. the polyacetylenes (1 - 3) were evaluated for their anti-inflammatory activity. Compounds 1 and 3 showed potent inhibitory activity against lipopolysaccharide-induced nitric oxide (N0) production in RAW267.7 macrophage cell with IC<sub>50</sub> value of 4.31 and 5.06 μM. respectively. Compound 1. strongly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in a concentration-dependent manner.
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