성기능개선, 원기증강 등에 효과가 있는 것으로 판매되고 있는 식품 등에서 발기부전치료제 및 그 유사물질 등이 불법적으로 혼입되어 검출되고 있다. 이들 부정물질이 혼입된 불량식품은 ...
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https://www.riss.kr/link?id=A102160934
2016
Korean
594
SCOPUS,KCI등재
학술저널
405-412(8쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
성기능개선, 원기증강 등에 효과가 있는 것으로 판매되고 있는 식품 등에서 발기부전치료제 및 그 유사물질 등이 불법적으로 혼입되어 검출되고 있다. 이들 부정물질이 혼입된 불량식품은 ...
성기능개선, 원기증강 등에 효과가 있는 것으로 판매되고 있는 식품 등에서 발기부전치료제 및 그 유사물질 등이 불법적으로 혼입되어 검출되고 있다. 이들 부정물질이 혼입된 불량식품은 안전성과 유효성이 입증되지 않았기 때문에 국민건강을 위협할 수 있다. 그러므로 본 연구에서는 식품과 가짜 발기부전치료제에 불법 혼입된 부정물질을 모니터링하기 위하여, 해외 인터넷 사이트와 오프라인 매장에서 성기능개선, 원기증진을 표방하는 식품과 최음제, 가짜 발기부전치료제 161건을 구입하였다. 시험방법의 유효성 검증을 위하여 선택성, 직선성, 검출한계, 정량한계, 정확성, 정밀성을 검토하였다. LC-PDA와 LC-MS/MS를 이용하여 부정물질 54종을 동시분석한 결과, 48건의 시료에서 7종의 부정물질(요힘빈, 이카린, 실데나필, 타다라필, 클로로프레타다라필, 데메틸실데나필, 디메틸치오실데나필)이 검출되었다. 성기능개선이나 최음제로 판매되는 제품에는 부정물질이 혼입될 가능성이 있으므로, 이들 제품을 구입할 때는 각별한 주의가 필요하다.
다국어 초록 (Multilingual Abstract)
Illegally adulterated compounds, such as impotency drugs and their synthetic analogues, which have been purported to enhance sexual potency or mood, have been constantly detected in foods including dietary supplements. The adulterated foods with these...
Illegally adulterated compounds, such as impotency drugs and their synthetic analogues, which have been purported to enhance sexual potency or mood, have been constantly detected in foods including dietary supplements. The adulterated foods with these illegal compounds may threaten public health because their safety and efficacy have not been verified. This study was aimed at investigating illegal compounds in foods and counterfeit products. 54 illegal compounds were assayed using a simultaneous analytical method involving liquid chromatography equipped with photo diode array (LC-PDA) and LC coupled with tandem mass spectrometry (LC-MS/MS). The method was validated in terms of selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), precision and accuracy. In 48 of 161 samples, we identified 7 different illegal compounds, including sildenafil, tadalafil, chlropretadalafil, demethylsildenafil, dimethylthiosildenafil, icariin and yohimbine. When purchasing products marketed for erectile dysfunction or aphrodisiacs, ulmost care should be taken owing to the possible presence of these illegal compounds.
참고문헌 (Reference)
1 Gur S, "Update on drug interactions with phosphodiesterase-5inhibitors prescribed as first-line therapy for patients with erectile dysfunction or pulmonary hypertension" 14 : 265-269, 2013
2 Venhuis BJ, "Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements:A history, analytical aspects and health risks" 69 : 196-208, 2012
3 Shin MH, "Studies on the Sildenafils in Foods" Ministry of Food and Drug Safety 459-465, 2002
4 Singh S, "Strategies for characterizing sildenafil, vardenafil, tadalafil, and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs" 28 : 13-28, 2009
5 Shin C, "Spectral assignments and reference data" 42 : 1060-1062, 2004
6 MFDS, "Monitoring and elucidation of novel illegal compounds in foods-about compounds relative to erectile dysfunction drugs and their analogues, steroids, etc" Ministry of Food and Drug Safety 2014
7 Shin MH, "Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction" 20 : 793-796, 2003
8 MFDS, "Food Sanitation Law"
9 MFDS, "Food Code"
10 Association of Official Analytical Chemists, "Appendix K: Guidelines for dietary supplements and botanicals"
1 Gur S, "Update on drug interactions with phosphodiesterase-5inhibitors prescribed as first-line therapy for patients with erectile dysfunction or pulmonary hypertension" 14 : 265-269, 2013
2 Venhuis BJ, "Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements:A history, analytical aspects and health risks" 69 : 196-208, 2012
3 Shin MH, "Studies on the Sildenafils in Foods" Ministry of Food and Drug Safety 459-465, 2002
4 Singh S, "Strategies for characterizing sildenafil, vardenafil, tadalafil, and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs" 28 : 13-28, 2009
5 Shin C, "Spectral assignments and reference data" 42 : 1060-1062, 2004
6 MFDS, "Monitoring and elucidation of novel illegal compounds in foods-about compounds relative to erectile dysfunction drugs and their analogues, steroids, etc" Ministry of Food and Drug Safety 2014
7 Shin MH, "Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction" 20 : 793-796, 2003
8 MFDS, "Food Sanitation Law"
9 MFDS, "Food Code"
10 Association of Official Analytical Chemists, "Appendix K: Guidelines for dietary supplements and botanicals"
11 Poon WT, "Analogues of erectile dysfunction drugs: An under-recognised threat" 13 : 359-363, 2007
12 Patel DN, "Adverse events associated with the use of complementary medicine and health supplements: An analysis of reports in the Singapore Pharmacovigilance database from 1998 to 2009" 50 : 481-489, 2009
13 Kearney T, "Adverse drug events associated with yohimbine-containing products: A retrospective review of the California poison control system reported cases" 47 : 827-829, 2010
전처리 조건에 따른 여주(Momordica charantia L.) 초절임의 쓴맛 감소와 품질평가
분류기법(Sorting task)을 이용한 시판 물냉면 육수의 감각특성에 대한 인식 연구
유전체 방벽 방전 콜드 플라즈마 기술을 이용한 양파 분말 미생물 안전성 향상 및 품질 보존
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | ![]() |
2010-11-23 | 학회명변경 | 영문명 : Korean Society Of Food Science And Biotechnology -> Korean Society of Food Science and Technology | ![]() |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2004-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2001-07-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
1999-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.03 | 1.03 | 1.1 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.11 | 1.08 | 2.013 | 0.18 |