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      KCI등재 SCOPUS

      원자현미경을 이용한 마이토마이신 노출 시간에 따른 공막 표면 콜라젠의 변화 관찰 = Effects of Mitomycin C on Scleral Collagen Fibrils According to Atomic Force Microscopy

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      https://www.riss.kr/link?id=A100524051

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      다국어 초록 (Multilingual Abstract)

      Purpose: To investigate the effects of mitomycin C on the scleral collagen surfaces using atomic force microscopy (AFM). Methods: Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of human scleral surfaces before and after one, three, and five minutes of 0.02% mitomycin C application. Based on AFM topography and deflection images of the collagen fibril, the morphological characteristics of scleral fibrils including the fibril diameter and D-period were measured using the line profile. Results: The sclera collagen fibril treated with 0.02% mitomycin C for one minute did not show any significant increases in mean fibril diameter (155.04 ± 17.46 nm) or mean D-periodicity (70.02 ± 3.33 nm), compared to those of the control group. However, the scleral collagen fibrils treated with 0.02% mitomycin C for three and five minutes showed significant increases in mean fibril diameter (182.33 ± 16.33 nm, 199.20 ± 12.40 nm, respectively) and mean D-periodicity (70.27 ± 13.66 nm, 72.75 ± 19.32 nm, respectively), compared to those of the control group. Conclusions: The present study examined the structural changes in the scleral collagen fibrils before and after mitomycin C application according to atomic force microscopy. The results indirectly suggest that three or more minutes of 0.02% mitomycin C application affects the morphology of scleral collagen. J Korean Ophthalmol Soc 2011;52(6):671-678
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      Purpose: To investigate the effects of mitomycin C on the scleral collagen surfaces using atomic force microscopy (AFM). Methods: Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of human scleral surf...

      Purpose: To investigate the effects of mitomycin C on the scleral collagen surfaces using atomic force microscopy (AFM). Methods: Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of human scleral surfaces before and after one, three, and five minutes of 0.02% mitomycin C application. Based on AFM topography and deflection images of the collagen fibril, the morphological characteristics of scleral fibrils including the fibril diameter and D-period were measured using the line profile. Results: The sclera collagen fibril treated with 0.02% mitomycin C for one minute did not show any significant increases in mean fibril diameter (155.04 ± 17.46 nm) or mean D-periodicity (70.02 ± 3.33 nm), compared to those of the control group. However, the scleral collagen fibrils treated with 0.02% mitomycin C for three and five minutes showed significant increases in mean fibril diameter (182.33 ± 16.33 nm, 199.20 ± 12.40 nm, respectively) and mean D-periodicity (70.27 ± 13.66 nm, 72.75 ± 19.32 nm, respectively), compared to those of the control group. Conclusions: The present study examined the structural changes in the scleral collagen fibrils before and after mitomycin C application according to atomic force microscopy. The results indirectly suggest that three or more minutes of 0.02% mitomycin C application affects the morphology of scleral collagen. J Korean Ophthalmol Soc 2011;52(6):671-678

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      참고문헌 (Reference)

      1 나윤수, "익상편 절제술 후 발생한 공막괴사에 대한 동종공막 이식수술 성적" 대한안과학회 46 (46): 3-3, 2005

      2 송해윤, "군날개절제술 후 발생한 공막연화증에서 무세포성 동종진피이식술" 대한안과학회 49 (49): 1685-1689, 2008

      3 Komai Y, "The three dimensional organization of collagen fibrils in the human cornea and sclera" 32 : 2244-2258, 1991

      4 Danshiitsoodol N, "The mitomycin C (MMC) binding protein from MMC producing microorganisms protects from the lethal effect of bleomycin" 360 : 398-408, 2006

      5 Spitznas M, "The fine structure of human scleral collagen" 71 : 68-, 1971

      6 Park DJ, "The effect of Mitomycin C on the success rate of endoscopic dacryo cystorhinostomy" 41 : 1674-1679, 2000

      7 Lee TS, "The effect of Mitomycin C eyedrops on prevention of intermal ostium obstruction after endonasal dacryocystorhinostomy" 39 : 1915-1920, 1998

      8 Oum BS, "The effect of Mitomycin C (MMC) on inhibition of cellular proliferation and type I collagen, laminin synthesis of pterygial mesenchymal cell" 40 : 712-720, 1999

      9 Rubinfeld RS, "Serious complications of topical mitomycin C after pterygium surgery" 99 : 1647-1654, 1992

      10 Rubinfeld RS, "Serious complications of topical mitomycin C after pterygium surgery" 99 : 1647-1654, 1992

      1 나윤수, "익상편 절제술 후 발생한 공막괴사에 대한 동종공막 이식수술 성적" 대한안과학회 46 (46): 3-3, 2005

      2 송해윤, "군날개절제술 후 발생한 공막연화증에서 무세포성 동종진피이식술" 대한안과학회 49 (49): 1685-1689, 2008

      3 Komai Y, "The three dimensional organization of collagen fibrils in the human cornea and sclera" 32 : 2244-2258, 1991

      4 Danshiitsoodol N, "The mitomycin C (MMC) binding protein from MMC producing microorganisms protects from the lethal effect of bleomycin" 360 : 398-408, 2006

      5 Spitznas M, "The fine structure of human scleral collagen" 71 : 68-, 1971

      6 Park DJ, "The effect of Mitomycin C on the success rate of endoscopic dacryo cystorhinostomy" 41 : 1674-1679, 2000

      7 Lee TS, "The effect of Mitomycin C eyedrops on prevention of intermal ostium obstruction after endonasal dacryocystorhinostomy" 39 : 1915-1920, 1998

      8 Oum BS, "The effect of Mitomycin C (MMC) on inhibition of cellular proliferation and type I collagen, laminin synthesis of pterygial mesenchymal cell" 40 : 712-720, 1999

      9 Rubinfeld RS, "Serious complications of topical mitomycin C after pterygium surgery" 99 : 1647-1654, 1992

      10 Rubinfeld RS, "Serious complications of topical mitomycin C after pterygium surgery" 99 : 1647-1654, 1992

      11 Wan Norliza WM, "Scleral melting 16 years after pterygium excision with topical Mitomycin C adjuvant therapy" 29 : 165-167, 2006

      12 Wan Norliza WM, "Scleral melting 16 years after pterygium excision with topical Mitomycin C adjuvant therapy" 29 : 165-167, 2006

      13 Kim JH, "Scleral grafts fer the cases of scleral perforation, scleral ectasia and scleral necrosis" 19 : 55-64, 1978

      14 Ross P, "Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5 FU in advanced esophagogastric cancer" 20 : 1996-2004, 2002

      15 Yamamoto S, "Observation of human corneal and scleral collagen fibrils by atomic force microscopy" 46 : 496-501, 2002

      16 Mao Y, "Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564" 6 : 251-263, 1999

      17 Solomon A, "Long-term effects of mitomycin C in pterygium surgery on scleral thickness and the conjunctival epithelium" 111 : 1522-1527, 2004

      18 Tarr KH, "Late complications of pterygium treatment" 64 : 496-505, 1980

      19 Manning CA, "Intraoperative mitomycin in primary pterygium excision" 104 : 844-848, 1997

      20 Khaw PT, "Intraoperative and post operative treatment with 5 fluorouracil and mitomycin c" 16 : 381-385, 1992

      21 Anderson RL, "Indications, complications and results with silicone stents" 86 : 1474-1487, 1979

      22 Anduze AL, "Indications for and complications of mitomycin C in pterygium surgery" 27 : 667-673, 1996

      23 Meller D, "Human cornea and sclera studied by atomic force microscopy" 288 : 111-118, 1997

      24 Spitznas M, "Fine structure of rabbit scleral collagen" 69 : 414-418, 1970

      25 Kwak JJ, "Endoscopic dacryocystorhinostomy with Mitomycin C application" 39 : 2211-2217, 1998

      26 Lin Z, "Effects of direct intravitreal dopamine injection on sclera and retina in form-deprived myopic rabbits" 24 : 543-550, 2008

      27 Lee KS, "Dacryocystorhinostomy with intraoperative Mitomycin C" 39 : 1909-1914, 1998

      28 Meek KM, "Corneal and scleral collagens a microscopist's perspective" 32 : 261-272, 2001

      29 Marshall GE, "Collagens in the aged human macular sclera" 12 : 143-153, 1993

      30 Kadler KE, "Collagen fibril formation" 316 : 1-11, 1996

      31 Keeley FW, "Characterization of collagen from normal human sclera" 39 : 533-542, 1984

      32 Fullwood NJ, "Atomic force microscopy of the cornea and sclera" 14 : 529-535, 1995

      33 Willems EW, "Antitumor antibiotics" Lippincott Williams & Wilkins 2006

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      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      2003-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.22 0.22 0.22
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      0.23 0.23 0.366 0.02
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