만성설사를 보이는 생후 4개월령의 한우 암컷 송아지에서 도체탕의 치료효과 = The effect of Dochetang for the treatment of chronic diarrhea in a 4 months-old-female Korean native calf

다국어 초록 (Multilingual Abstract)

This study was carried out to evaluate the effects of Dochetang for the treatment of chronic diarrhea in a 4 months-old-female Korean native calf. The calf was presented to the Wow Animal Clinic, Iksan with the history of chronic diarrhea for several weeks. The feces test did not reveal the presence of the parasites or microbes causing diarrhea in calf. The blood test was also negative to the virus that causes of diarrhea in calf. Adminstration of parenteral antibiotics resulted in improvement of the condition temporarily but diarrhea was recurred again after 2-3 weeks. Then the calf was treated with Dochetang administered orally once a day in an empty stomach for 15 days. Feces was significantly reduced in moisture on 7 days after initial treatment. On 9 days after initial treatment, the calf had normal appetite and defecation in physiological conditions. Blood samples were collected before administration and on 1, 2 and 3 weeks after initial administration of Dochetang for hematology and biochemistry. A significantly differences were observed in the white blood cell (WBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), albumin (ALB), glutamic pyrubic transaminase (GPT), inorganic phosphorus (IP) and magnesium (Mg), while no significant differences were seen in the red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), platelet (PLT), glucose (Glu), total protein (T-pro), glutamic oxaloacetic transaminase (GOT), blood urea nitrogen (BUN) and creatine (CRE). This study suggests that Dochetang administration can be a successful alternative therapeutic agent in instead of antibiotics for the treatment of chronic diarrhea in calves.

참고문헌 (Reference)

1 정효훈, "황백, 연교 및 감초 추출물을 이용한 국소제제의 Staphylococcus intermedius에 대한 항균효과" 한국임상수의학회 22 (22): 353-356, 2005

2 김곤섭, "한방사료 첨가제의 항균성 및 재래닭에서의 Campylobacter jejuni 방제효과" 한국임상수의학회 23 (23): 41-49, 2006

3 崔錫和, "송아지의 細菌性 泄瀉症에 對한 生蜂毒의 治療效果" 17 : 57-61, 2000

4 최석화, "생봉독을 이용한 세균성 설사 자돈의 치료효과" 16 : 150-154, 1999

5 심경미, "구강점막의 창상치유에 대한 식나무 추출물의 효과 王潔譯自" 55 43-60 44, 中草藥1988

6 朴潔煥, "當歸水鍼이 鎭痛果에 미치는 影響" 7 : 261-272, 1984

7 胡慧娟, "當歸之抗作用" 16 : 684-686, 1991

8 李尙仁, "漢藥臨床應用" 175-, 1982

9 陳存仁, "漢方醫學大辭典" 松嶽出版社 123-, 1990

10 裵元植, "最新韓方臨床學" 153-, 1981

11 "導滯湯과 導滯湯 合 理中湯 抽出物이 마우스의 防禦分子 生成 및 免疫反應에 미치는 影響" 圓光大學校大學院 1993

12 文錫哉, "導滯湯 extract가 胃腸管機能 및 腸內細菌에 미치는 影響" 8 : 30-52, 1987

13 王顯明, "中醫內科辨證學" 人民衛生出版社 300-302, 1984

14 "三種黃連의 抗菌力比較實驗" 圓光大學校大學院 1982

15 Michell AR, "The comparative effectiveness of three commercial oral solutions in correcting fluid,electrolyte and acid-base disturbances caused by calf diarrhoea" 148 : 507-522, 1992

16 Tzipori S, "The aetiology and diagnosis of calf diarrhoea" 108 : 510-515, 1981

17 Cornaglia EM, "Reduction in morbidity due to diarrhea in nursing beef calves by use of an inactivated oil-adjuvanted rotavirus-Escherichia coli vaccine in the dam" 30 : 191-202, 1992

18 Fuller R, "Probiotics in man and animals" 66 : 365-378, 1989

19 Morrill JL, "Plasma protein and a probiotic as ingredients in milk replacer" 78 : 902-907, 1995

20 Bendali F, "Pattern of diarrhoea in newborn beef calves in south-west France" 30 : 61-74, 1999

21 Snodgrass DR, "Passive immunity in calf rotavirus infections:maternal vaccination increases and prolongs immnunoglobulin G1 antibody secretion in milk" 28 : 344-349, 1980

22 Kennedy M, "Overuse of antibiotics leads to “super bug”" 99 : 22-28, 2000

23 Virtala AM, "Morbidity from nonrespiratory diseases and mortality in dairy heifers during the first three months of life" 208 : 2043-2046, 1996

24 Grove-White DH, "Monitoring and management of acidosis in calf diarrhoea" 91 : 195-198, 1998

25 Michanek P, "Milk intake before first colostrum in newborn dairy calves.Effect on intestinal transmission of macromolecules" 73 : 480-483, 1990

26 Reynolds DJ, "Microbiology of calf diarrhoea in southern Britain" 119 : 34-39, 1986

27 Kuczynska E, "Method for detection and enumeration of Cryptosporidium parvum oocysts in feces,manures,and soils" 65 : 2820-2826, 1999

28 Kimman TG, "Local and systemic antibody response to bovine respiratory syncytial virus infection and reinfection in calves with and without maternal antibodies" 25 : 1097-1106, 1987

29 Weber N, "In vitro virucidal effects of Allium sativum(garlic)extract and compounds" 58 : 417-423, 1992

30 Feldberg RS, "In vitro mechanism of inhibition of bacterial cell growth by allicin" 32 : 1763-1768, 1988

31 Saif LJ, "Enteric viral infections of calves and passive immunity" 68 : 206-228, 1985

32 Heinrichs AJ, "Effects of mannan oligosaccharide or antibiotics in neonatal diets on health and growth of dairy calves" 86 : 4064-4069, 2003

33 Abe F, "Effect of administration of bifidobacteria and lactic acid bacteria to newborn calves and piglets" 78 : 2838-2846, 1995

34 Snodgrass DR, "Diarrhoea in dairy calves reduced by feeding colostrum from cows vaccinated with rotavirus" 32 : 70-73, 1982

35 Stott GH, "Colostral immunoglobulin transfer in calves I.Period of absorption" 62 : 1632-1638, 1979

36 Kasari TR, "Clinical evaluation of sodium bicarbonate,sodium L-lactate,and sodium acetate for the treatment of acidosis in diarrheic calves" 187 : 392-397, 1985

37 Quigley JD 3rd, "Body weight gain,feed efficiency,and fecal scores of dairy calves in response to galactosyl-lactose or antibiotics in milk replacers" 80 : 1751-1754, 1997

38 Davis LE, "Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum" 34 : 651-653, 1990