Mechanisms by Which Atopic Dermatitis Predisposes to Food Allergy and the Atopic March

다국어 초록 (Multilingual Abstract)

The Atopic march denotes the progression from atopic dermatitis (AD) to the development of other allergic disorders such as immunoglobulin (Ig) E-mediated food allergy, allergic rhinitis and asthma in later childhood. There is increasing evidence from prospective birth cohort studies that early-onset AD is a risk factor for other allergic diseases or is found in strong association with them. Animal studies now provide mechanistic insights into the pathways that may be responsible for triggering the progression from the skin barrier dysfunction seen in AD to epicutaneous sensitization, food allergy and allergic airway disorders. Recent large randomized controlled trials have demonstrated the efficacy of early interventions targeted at AD and food allergy prevention. These show great promise for research into future strategies aimed at prevention of the atopic march.

참고문헌 (Reference)

1 Fiocchi A, "World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention(GLAD-P) : probiotics" 8 : 4-, 2015

2 Martin PE, "Which infants with eczema are at risk of food allergy? Results from a population-based cohort" 45 : 255-264, 2015

3 Lack G, "Update on risk factors for food allergy" 129 : 1187-1197, 2012

4 Natsume O, "Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema(PETIT) : a randomised, double-blind, placebo-controlled trial" 389 : 276-286, 2017

5 Han H, "Thymic stromal lymphopoietin(TSLP)-mediated dermal inflammation aggravates experimental asthma" 5 : 342-351, 2012

6 Margolis DJ, "Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis" 150 : 254-259, 2014

7 Lowe AJ, "The temporal sequence of allergic sensitization and onset of infantile eczema" 37 : 536-542, 2007

8 Ashley SE, "The skin barrier function gene SPINK5 is associated with challenge-proven IgE-mediated food allergy in infants" 72 : 1356-1364, 2017

9 Lowe AJ, "The skin as a target for prevention of the atopic march" 120 : 145-151, 2018

10 Alduraywish SA, "The march from early life food sensitization to allergic disease : a systematic review and meta-analyses of birth cohort studies" 71 : 77-89, 2016

11 Cianferoni A, "The importance of TSLP in allergic disease and its role as a potential therapeutic target" 10 : 1463-1474, 2014

12 Marenholz I, "The genetics of the skin barrier in eczema and other allergic disorders" 15 : 426-434, 2015

13 Hill DA, "The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children : a retrospective cohort study" 16 : 133-, 2016

14 Hill DA, "The atopic march : critical evidence and clinical relevance" 120 : 131-137, 2018

15 Mallol J, "The International Study of Asthma and Allergies in Childhood (ISAAC) phase three: a global synthesis" 41 : 73-85, 2013

16 Tauber M, "Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis" 137 : 1272-1274, 2016

17 Forbes-Blom E, "Staphylococcal-derived superantigen enhances peanut induced Th2 responses in the skin" 42 : 305-314, 2012

18 Jiang H, "Skin thymic stromal lymphopoietin promotes airway sensitization to inhalant house dust mites leading to allergic asthma in mice" 67 : 1078-1082, 2012

19 Kelleher MM, "Skin barrier impairment at birth predicts food allergy at 2 years of age" 137 : 1111-1116, 2016

20 Kelleher M, "Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year" 135 : 930-935, 2015

21 Czarnowicki T, "Skin barrier and immune dysregulation in atopic dermatitis : an evolving story with important clinical implications" 2 : 371-379, 2014

22 김병의, "Significance of Skin Barrier Dysfunction in Atopic Dermatitis" 대한천식알레르기학회 10 (10): 207-215, 2018

23 Ferreira MA, "Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology" 49 : 1752-1757, 2017

24 Beasley R, "Risk factors for asthma : is prevention possible" 386 : 1075-1085, 2015

25 Du Toit G, "Randomized trial of peanut consumption in infants at risk for peanut allergy" 372 : 803-813, 2015

26 Ohya Y, "Prevention of Allergy via Cutaneous Intervention (PACI) study. Trial registration ID: UMIN000028043" National Center for Child Health and Development

27 Tran MM, "Predicting the atopic march : results from the Canadian Healthy Infant Longitudinal Development Study" 141 : 601-607, 2018

28 Tsilochristou OA, "Pediatric allergic rhinitis and asthma : can the march be halted" 15 : 431-440, 2013

29 Yagami A, "Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan" 140 : 879-881, 2017

30 Boussault P, "Oat sensitization in children with atopic dermatitis : prevalence, risks and associated factors" 62 : 1251-1256, 2007

31 Barker JN, "Null mutations in the filaggrin gene(FLG)determine major susceptibility to early-onset atopic dermatitis that persists into adulthood" 127 : 564-567, 2007

32 Marenholz I, "Meta-analysis identifies seven susceptibility loci involved in the atopic march" 6 : 8804-, 2015

33 Ewald DA, "Meta-analysis derived atopic dermatitis(MADAD)transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways" 8 : 60-, 2015

34 Walker MT, "Mechanism for initiation of food allergy : dependence on skin barrier mutations and environmental allergen costimulation" 141 : 1711-1725, 2018

35 Berdyshev E, "Lipid abnormalities in atopic skin are driven by type 2 cytokines" 3 : 98006-, 2018

36 Johansson E, "KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis" 140 : 595-598, 2017

37 Alduraywish SA, "Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies" 28 : 30-37, 2017

38 Strachan DP, "Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort" 312 : 1195-1199, 1996

39 Galand C, "IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells" 138 : 1356-1366, 2016

40 Jones AL, "Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis" 137 : 1247-1248, 2016

41 Sicherer SH, "Food allergy : epidemiology, pathogenesis, diagnosis, and treatment" 133 : 291-307, 2014

42 Cole C, "Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis" 134 : 82-91, 2014

43 Lack G, "Factors associated with the development of peanut allergy in childhood" 348 : 977-985, 2003

44 Noti M, "Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis" 133 : 1390-1399, 2014

45 Lack G, "Epidemiologic risks for food allergy" 121 : 1331-1336, 2008

46 Stremnitzer C, "Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL/6 mice, independent of functional TLR4" 69 : 741-751, 2014

47 Spergel JM, "Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice" 101 : 1614-1622, 1998

48 Deckers J, "Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells" 140 : 1364-1377, 2017

49 Bartnikas LM, "Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis" 131 : 451-460, 2013

50 Akei HS, "Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses" 118 : 62-69, 2006

51 Glatz M, "Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis" 13 : e0192443-, 2018

52 Simpson EL, "Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention" 134 : 818-823, 2014

53 Chalmers JR, "Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children(The BEEP trial) : protocol for a randomised controlled trial" 18 : 343-, 2017

54 von Kobyletzki LB, "Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort" 12 : 11-, 2012

55 Saunes M, "Early eczema and the risk of childhood asthma : a prospective, population-based study" 12 : 168-, 2012

56 Strid J, "Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response" 34 : 2100-2109, 2004

57 Belgrave DC, "Developmental profiles of eczema, wheeze, and rhinitis : two population-based birth cohort studies" 11 : e1001748-, 2014

58 Gustafsson D, "Development of allergies and asthma in infants and young children with atopic dermatitis--a prospective follow-up to 7 years of age" 55 : 240-245, 2000

59 Johansson E, "Contribution of an impaired epithelial barrier to the atopic march" 120 : 118-119, 2018

60 Hussain M, "Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy" 141 : 223-234, 2018

61 Carlsten C, "Atopic dermatitis in a high-risk cohort : natural history, associated allergic outcomes, and risk factors" 110 : 24-28, 2013

62 Martinez FD, "Asthma and wheezing in the first six years of life" 332 : 133-138, 1995

63 Hirota T, "Association study of childhood food allergy with genome-wide association studies-discovered loci of atopic dermatitis and eosinophilic esophagitis" 140 : 1713-1716, 2017

64 Horimukai K, "Application of moisturizer to neonates prevents development of atopic dermatitis" 134 : 824-830, 2014

65 Dunkin D, "Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner" 128 : 1251-1258, 2011

66 Lowe AJ, "Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age" 28 : 384-390, 2017

67 Lowe AJ, "A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization : the PEBBLES pilot study" 178 : e19-e21, 2018

68 Fallon PG, "A homozygous frameshift mutation in the mouse FLG gene facilitates enhanced percutaneous allergen priming" 41 : 602-608, 2009

69 Weidinger S, "A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis" 22 : 4841-4856, 2013