색소성 피부질환에 대한 구리증기 레이저 치료후 임상, 조직, 면역조직화학적 소견 = Clinicopathologic and Immonohistochemical Findings of Several Pigmented Skin Lesions after Copper Vapor Laser Treatment색소성 피부질환에 대한 구리증기 레이저 치료후 임상, 조직, 면역조직화학적 소견

다국어 초록 (Multilingual Abstract)

Background : There have been only a few morphological studies after laser treatment of pigmented skin lesions. Objective : The purpose was to investigate the clinicopathologic and immunohistochemical changes following copper vapor laser treatment of superficial pigmented skin lesions. Methods : Three patients with Becker`s nevus, １ patient with partial unilateral lentiginosis, and １ patient with nevus spilus were irradiated with copper vapor laser. Forty-two biopsies were taken before, immediately after, and ３ months after laser treatment. Hematoxylin-eosin, Fontana-Masson, and S-１００ protein staining were performed for the evaluation of the histopathologic and immunohistochemical findings of the specimens. Results : Clinically, immediate greyish whitening, immediate erythema, and delayed edema were observed immediately after copper vapor treatment. Histopathologically, suprabasilar separation with elongated cells in the basal cell layer was observed immediately after laser treatment. A few vacuolated cells were found mainly in the basal cell layer. Fontana-Masson and S-１００ protein staining positivity decreased a lot in the epidermis, but they hardly decreased in the dermis immediately after laser treatment. Conclusion : For the treatment of pigmented skin lesions, copper vapor laser was more effective in the epidermal pigmented structures than the dermal pigmented structures. Selective photothermolysis of melanosome was not so prominent after copper vapor laser treatment. (Korean J Dermatol ２００２;４０(１２) : １４６８∼１４７３)