Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics

다국어 초록 (Multilingual Abstract)

Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments ofstroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease.
However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignoranceof biodistribution after administration, and complex intercellular communication between brain cells, make braintheranostics application difficult, especially when it comes to clinical application. So, a more thorough understanding of eachaspect is needed. In this review, we focus on recent studies regarding the role of exosomes in intercellular communication of braincells, therapeutic effect of graphene quantum dots, transcriptomics/epitranscriptomics approach for target selection, andin vitro/in vivo considerations.

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