국산 프로폴리스의 Helicobacter pyrori 억제효과|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Propolis possesses antimicrobial, anti-inflammatory, anaesthetic and immunostimulating activities. The aim of this study was to evaluated chemical composition and in vitro anti-Helicobacter pylori activity of eight propolis ethanolic extracts form different region in Korea. The chemical composition of eight Korean propolis was investicated by absorption spectrophotomety and UHPLC. Total penolic and total flavonoids content ranged between $21{\pm}1.5$ and $31{\pm}1.8$ gallic acid g/100 g and $7.2{\pm}0.9$ and $24.4{\pm}1.9$ quercetin g/100 g, respectively. The p-coumaric acid as standard components content ranged between $0.29{\pm}0.00$ and $2.34{\pm}0.02mg/g$ using UHPLC. Cinnamic acid content between $0.43{\pm}0.00$ and $1.33{\pm}0.01mg/g$. 80% ethanolic extract of propolis against H. pylori was evaluated by using the disc diffusion method. Ethanol was used as a control. Mean diameters of H. pylori growth inhibition using $10{\mu}g/mL$, $50{\mu}g/mL$ or $100{\mu}g/mL$ ethanol propolis per disc were 0, ranging from 0.9 to 2.1 mm and from 1.9 to 3.5 mm, respectively. In conclusion, variation in the chemical composition of Korean propolis were mainly due to the difference in the preferred regional plants visited by honeybees. Also Korean propolis possesses considerable antibacterial activity against H. pylori. There was not confirmed a correlation between the chemical composion contens and anti-H. pylori effect. The potential of propolis in the prevention or treatment of H. pylori infection is worth further extensive evaluation.

번역하기

참고문헌 (Reference)

1 Kurek-Górecka A, "Structure and antioxidant activity of polyphenols derived from propolis" 19 : 78-101, 2013

2 Spinzi GC, "Seven-day triple therapy with ranitidine bismuth citrate or omeprazole and two antibiotics for eradication of Helicobacter pylori in duodenal ulcer : a multicentr, randomized, single-blind study" 14 : 325-330, 2000

3 Kim NY, "Seroprevalence of Helicobacter pylori infection in asymptomatic people in Korea" 59 : 388-392, 2000

4 Banskota AH, "Recent progress in pharmacological research of propolis" 15 : 561-571, 2001

5 Silva-Carvalho R, "Propolis: A complex natural product with a plethora of biological activities that can be explored for drug development" 2015

6 Vassya Bankova, "Propolis volatile compounds: chemical diversity and biological activity: a review" Springer Nature 8 (8): 28-, 2014

7 Salatino A, "Propolis research and the chemistry of plant products" 28 : 925-936, 2011

8 Kusters JG, "Pathogenesis of Helicobacter pylori infection" 19 : 449-490, 2006

9 Misiewicz JJ, "One week triple therapy for Helicobacter pylori : A multicentr comparative study" 41 : 735-739, 1997

10 Guzman JD, "Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity" 19 : 19292-19349, 2014