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      기억형 경도인지장애 환자의 의미적 측면에서의 언어장애 특성 = Features of Semantic Language Impairment in Patients with Amnestic Mild Cognitive Impairment

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      https://www.riss.kr/link?id=A103919613

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      다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

      Background: To elucidate the earliest changes of language function in patients with dementia of Alzheimer’s type (DAT), performance on the various semantic language tasks were compared between patients with amnestic mild cognitive impairment (aMCI) (n=20), mild DAT (n=20) and normal cognition elderly individuals (NC, n=20). Methods: Language tasks included levels of word, sentence and discourse. In the word level, confrontation naming test (Korean version-Boston Naming Test, K-BNT) and the verbal fluency (semantic and phonemic fluency) tasks were used. In the sentence level, the verbal definition tasks including 24 nouns four categories were used. In the discourse level, the Boston Cookie-Theft picture description task was used. The picture description task was analyzed for both productive aspect (total number of sentences, total number of phrases and phrases per sentence) and semantic aspect (ratio of CIU: Correct Information Unit). Results: The results from this study are as follow: 1) In the confrontation naming test, mild DAT group showing worse performances than the NC and aMCI group. However, no differences were observed between the NC and aMCI group. 2) The performances of verbal fluency task showed significantly differences between the all groups. 3) In the verbal definition task, performances of NC group showing better performances than aMCI and mild DAT group. However, no differences were observed between the aMCI and mild DAT group. 4) In the picture description task, performances of the aMCI and mild DAT group were non-informative and inefficient in semantic aspect compared to the NC group. However, no differences were observed between the three groups on productive aspect. Conclusions: These results demonstrated that the deficit of semantic language is readily identified in the aMCI stage, and it can be revealed by tasks of sentence and discourse level.
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      Background: To elucidate the earliest changes of language function in patients with dementia of Alzheimer’s type (DAT), performance on the various semantic language tasks were compared between patients with amnestic mild cognitive impairment (aMCI) ...

      Background: To elucidate the earliest changes of language function in patients with dementia of Alzheimer’s type (DAT), performance on the various semantic language tasks were compared between patients with amnestic mild cognitive impairment (aMCI) (n=20), mild DAT (n=20) and normal cognition elderly individuals (NC, n=20). Methods: Language tasks included levels of word, sentence and discourse. In the word level, confrontation naming test (Korean version-Boston Naming Test, K-BNT) and the verbal fluency (semantic and phonemic fluency) tasks were used. In the sentence level, the verbal definition tasks including 24 nouns four categories were used. In the discourse level, the Boston Cookie-Theft picture description task was used. The picture description task was analyzed for both productive aspect (total number of sentences, total number of phrases and phrases per sentence) and semantic aspect (ratio of CIU: Correct Information Unit). Results: The results from this study are as follow: 1) In the confrontation naming test, mild DAT group showing worse performances than the NC and aMCI group. However, no differences were observed between the NC and aMCI group. 2) The performances of verbal fluency task showed significantly differences between the all groups. 3) In the verbal definition task, performances of NC group showing better performances than aMCI and mild DAT group. However, no differences were observed between the aMCI and mild DAT group. 4) In the picture description task, performances of the aMCI and mild DAT group were non-informative and inefficient in semantic aspect compared to the NC group. However, no differences were observed between the three groups on productive aspect. Conclusions: These results demonstrated that the deficit of semantic language is readily identified in the aMCI stage, and it can be revealed by tasks of sentence and discourse level.

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      참고문헌 (Reference)

      1 오혜경, "알츠하이머병과 혈관성 치매 환자의의미기억과 관련된 언어과제의 수행 차이" 한국언어치료학회 19 (19): 73-84, 2010

      2 김수정, "노년층의 명사 정의하기 특성" 한국언어청각임상학회 17 (17): 107-117, 2012

      3 최현주, "구어유창성과 그림설명과제를 통한 경도인지장애(MCI) 환자의 언어손상 검출" 한국언어청각임상학회 16 (16): 171-184, 2011

      4 최현주, "경도 알츠하이머형 치매 환자의 범주유창성 과제에서의 범주특정적 손상 특징" 한국언어청각임상학회 15 (15): 572-580, 2010

      5 Lee E, An SK, Oh BH, Kim KH, Lee YH, Ohrr HC, Kim SM. A neurocognitive assessment : mild dementia of the Alzheimer type, questionable dementia, "and non-demented elderly women" 39 : 167-182,

      6 Martin A, "Word production and comprehension in Alzheimer’s disease: the breakdown of semantic knowledge" 19 : 124-141, 1983

      7 Diesfeldt HFA, "Verbal fluency in senile dementia: an analysis of search and knowledge" 4 : 231-239, 1985

      8 Duong A, "The nature of lexicosemantic processing deficits in mild cognitive impairment" 44 : 1928-1935, 2006

      9 Perry RJ, "The nature and staging of attention dys function in early (minimal and mild) Alzheimer’s disease: relationship to episodic and semantic memory impairment" 38 : 252-271, 2000

      10 Im E, "The in formativeness and efficiency of the connected speech samples in Korean fluent aphasics" 6 : 374-391, 2001

      1 오혜경, "알츠하이머병과 혈관성 치매 환자의의미기억과 관련된 언어과제의 수행 차이" 한국언어치료학회 19 (19): 73-84, 2010

      2 김수정, "노년층의 명사 정의하기 특성" 한국언어청각임상학회 17 (17): 107-117, 2012

      3 최현주, "구어유창성과 그림설명과제를 통한 경도인지장애(MCI) 환자의 언어손상 검출" 한국언어청각임상학회 16 (16): 171-184, 2011

      4 최현주, "경도 알츠하이머형 치매 환자의 범주유창성 과제에서의 범주특정적 손상 특징" 한국언어청각임상학회 15 (15): 572-580, 2010

      5 Lee E, An SK, Oh BH, Kim KH, Lee YH, Ohrr HC, Kim SM. A neurocognitive assessment : mild dementia of the Alzheimer type, questionable dementia, "and non-demented elderly women" 39 : 167-182,

      6 Martin A, "Word production and comprehension in Alzheimer’s disease: the breakdown of semantic knowledge" 19 : 124-141, 1983

      7 Diesfeldt HFA, "Verbal fluency in senile dementia: an analysis of search and knowledge" 4 : 231-239, 1985

      8 Duong A, "The nature of lexicosemantic processing deficits in mild cognitive impairment" 44 : 1928-1935, 2006

      9 Perry RJ, "The nature and staging of attention dys function in early (minimal and mild) Alzheimer’s disease: relationship to episodic and semantic memory impairment" 38 : 252-271, 2000

      10 Im E, "The in formativeness and efficiency of the connected speech samples in Korean fluent aphasics" 6 : 374-391, 2001

      11 Garrard P, "The effects of very early Alzheimer’s disease on the characteristics of writing by renowned author" 128 : 250-260, 2005

      12 Norlin PF, "The development of relational arcs in the lexical semantic memory structures of young children" 17 : 697-710, 1980

      13 Kim J, "The characteristics of cognitive function in mild cognitive impairment" 12 : 287-292, 2006

      14 Goodglass H, "The assessment aphasia and related disorders" PA: Lea & Febiger 1983

      15 Morris JC, "The Clinical Dementia Rating (CDR): current version and scoring rules" 43 : 2412-2414, 1983

      16 Bschor T, "Spontaneous speech of patients with dementia of Alzheimer’s type and mild cognitive impairment" 13 : 289-298, 2001

      17 Kang Y, "Seoul Neuropsychological Screening Battery: SNSB" 2003

      18 Chertkow H, "Semantic memory loss in dementia of Alzheimer’s type" 113 : 397-417, 1990

      19 Hodges JR, "Semantic memory impairment in Alzheimer’s disease: failure of access or degraded knowledge" 30 : 301-314, 1992

      20 Daum I, "Semantic memory impairment in Alzheimer’s disease" 18 : 648-665, 1996

      21 Abeysinghe SH, "Semantic memory deterioration in Alzheimer’s subject: evidence from word association, definition, and associate ranking tasks" 33 : 574-582, 1993

      22 Adlam A, "Semantic knowledge in mild cognitive impairment" 42 : 675-684, 2006

      23 Carlomagno S, "Referential communication in Alzheimer’s type dementia" 41 : 520-534, 2005

      24 Johnson CJ, "Qualitative development in the content and form of children’s definitions" 38 : 612-629, 1995

      25 Funnell E, "Progressive loss of access to spoken word forms in a case of Alzheimer’s disease" 243 : 173-179, 1991

      26 Albert MS, "Preclinical prediction of AD using neuropsychological tests" 7 : 631-639, 2001

      27 최현주, "Performances in a Picture Description Task in Japanese Patients with Alzheimer’s Disease and with Mild Cognitive Impairment" 한국언어청각임상학회 14 (14): 326-337, 2009

      28 Giles E, "Performance on the Boston Cookie Theft picture description task in patients with early dementia of the Alzheimer’s type: Missing information" 10 : 395-408, 1996

      29 Chen P, "Patterns of cognitive decline in pre-symptomatic Alzheimer’s disease: a prospective community study" 58 : 853-858, 2001

      30 Tabert MH, "Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment" 63 : 916-924, 2006

      31 Choi KG, "Neuropathology of MCI: View from relationship with aging and Alzheimer’s disease" 2 : 101-107, 2003

      32 Bowles NL, "Naming errors in healthy aging and dementia of Alzheimer type" 23 : 519-534, 1987

      33 Lee GJ, "Naming deficits in patients with dementia of Alzheimer type" Ewha Womans University 2002

      34 Ribeiro F, "Mild cognitive impairment: Deficits in cognitive domains other than memory" 21 : 284-290, 2006

      35 Petersen RC, "Mild cognitive impairment as a diagnostic entity" 256 : 183-194, 2004

      36 Portet F, "Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease" 77 : 714-718, 2006

      37 Clifford R, "Magnetic resonance imaging. In RC Petersen, Mild cognitive impairment" Oxford University Press 2003

      38 Taler V, "Language performance in Alzheimer’s disease and mild cognitive impairment: a comparative review" 30 : 501-556, 2008

      39 Hier DB, "Language disintegration in dementia: effects of etiology and severity" 25 : 117-133, 1985

      40 Kim H, "Korean version-Boston Naming Test (K-BNT)" Hakji Press 1997

      41 강연욱, "K-MMSE(Korean-Mini Mental State Examination)의 노인 규준 연구" 한국심리학회 25 (25): 1-12, 2006

      42 Venneri A, "Impoverishment of spontaneous language and the prediction of Alzheimer’s disease" 128 : E27-, 2005

      43 Fromm D, "Functional communication in Alzheimer’s disease" 54 : 535-540, 1989

      44 Kang B, "Frequency of Korean" Hankookmunhwasa 2009

      45 Bayles KA, "Effect of working memory deficits on the communicative functioning of Alzheimer’s dementia patient" 36 : 209-219, 2003

      46 Doosan Dong-A Editorial, "Dong-A Korean language dictionary" Doosan Dong-A 2010

      47 Salmon DP, "Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer’s disease: implications for the integrity of semantic memory" 5 : 692-703, 1999

      48 Forbes-McKay KE, "Detecting subtle spontaneous language decline in early Alzheimer’s disease with picture description task" 26 : 243-254, 2005

      49 Choi Y, "Comparison between conversations and picture description utterances of healthy Korean elderly" Yonsei University 2007

      50 Lim SH, "Changes in word definition ability depending on severity in patients with Alzheimer’s disease" Ewha Womans University 2010

      51 Hills AE, "Category-specific naming and comprehension impairment: a double dissociation" 114 : 2081-2094, 1991

      52 Cooper DB, "Category fluency in mild cognitive impairment: reduced effect of practice in testretest conditions" 18 : 120-122, 2004

      53 Chereney H, "An investigation of confrontation naming performance in Alzheimer’s dementia as a function of disease severity" 5 : 423-441, 1996

      54 Dubois B, "Amnestic MCI or prodromal Alzheimer’s disease?" 3 : 246-248, 2004

      55 Fonseca LC, "Alzheimer’s disease: relationship between cognitive aspects and power and coherence EEG measures" 69 : 875-881, 2011

      56 Kang Y, "A validity study on the Korean Mini-Mental State Examination (KMMSE) in dementia patients" 15 : 300-308, 1997

      57 Nicholas LE, "A system for quantifying the informativeness and efficiency of the connected speech of adults with aphasia" 36 : 338-350, 1993

      58 Jung Y, "A study for the informativeness and efficiency of spontaneous speech depending on task type in patients with Alzheimer’s diseas" Ewha Womans University 2008

      59 Kwon M, "A study for analyzing speech of Korean adults with CIU scoring system" 3 : 35-49, 1993

      60 Groves-Wright K, "A comparison of verbal and written language in Alzheimer’s disease" 37 : 109-130, 2004

      61 Choi H, "A comparison of the performances of confrontation naming test and verbal fluency task in patients with prodromal Alzheimer’s disease and mild Alzheimer’s disease" 15 : 111-118, 2008

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