알츠하이머병 환자에서의 삶의 질 평가 = Assessment of the Quality of Life in Patients With Alzheimer’s Disease

다국어 초록 (Multilingual Abstract)

Backgrounds: Evaluating quality of life (QoL) in people with dementia has become increasingly valued, especially in assessing the effectiveness of interventions or making treatment decisions. However, limited information exists regarding dementia patients’ QoL in Korea. The aim of our investigation was to determine if the severity of dementia could affect the QoL of patients with dementia and the relationship between QoL score and the scores of other cognitive domains, especially, the attention.
Methods: Two hundred and sixty eight subjects with varying degree of cognitive dysfunction underwent assessment of Korean-Mini Mental Status Examination (K-MMSE), digit span, trail making test (TMT), Korean-Instrumental Activity Daily Living (K-IADL), Geriatric Depression Scale (GDS), Clinical Dementia Rating Scale (CDR), attention and their QoL using standardized neuropsychological tests and questionnaires. We administered the QoL in Alzheimer’s disease (QoL-AD) scale and attention questionnaire to the subjects.
Results: QoL-AD score had a positive correlation with K-MMSE score (r=0.38, p<0.0001) while it showed a negative correlation with GDS (r=-0.62 p<0.0001). QoL-AD score also showed a significant correlation with attention status of the patients with dementia (r=0.48, p<0.0001). QoL-AD score for patient appeared to be affected by educational factors.
Conclusions: QoL-AD may be used as an effective tool to assess QoL as well as cognitive functions of patients with varying degree of dementia.

다국어 초록 (Multilingual Abstract)

Backgrounds: Evaluating quality of life (QoL) in people with dementia has become increasingly valued, especially in assessing the effectiveness of interventions or making treatment decisions. However, limited information exists regarding dementia patients’ QoL in Korea. The aim of our investigation was to determine if the severity of dementia could affect the QoL of patients with dementia and the relationship between QoL score and the scores of other cognitive domains, especially, the attention.
Methods: Two hundred and sixty eight subjects with varying degree of cognitive dysfunction underwent assessment of Korean-Mini Mental Status Examination (K-MMSE), digit span, trail making test (TMT), Korean-Instrumental Activity Daily Living (K-IADL), Geriatric Depression Scale (GDS), Clinical Dementia Rating Scale (CDR), attention and their QoL using standardized neuropsychological tests and questionnaires. We administered the QoL in Alzheimer’s disease (QoL-AD) scale and attention questionnaire to the subjects.
Results: QoL-AD score had a positive correlation with K-MMSE score (r=0.38, p<0.0001) while it showed a negative correlation with GDS (r=-0.62 p<0.0001). QoL-AD score also showed a significant correlation with attention status of the patients with dementia (r=0.48, p<0.0001). QoL-AD score for patient appeared to be affected by educational factors.
Conclusions: QoL-AD may be used as an effective tool to assess QoL as well as cognitive functions of patients with varying degree of dementia.

참고문헌 (Reference)

1 신희영, "지역사회 거주 치매환자에서 한국판 삶의 질-알쯔하이머병 척도 개발을 위한 예비연구" 대한예방의학회 39 (39): 243-248, 2006

2 Thorgrimsen L, "Whose quality of life is it anyway? The validity and reliability of the quality of life-Alzheimer’s Disease (QoL-AD) scale" 17 : 201-208, 2003

3 Sands LP, "What explains differences between dementia patient’ and their caregivers’ ratings of patient quality of life?" 15 : 181-198, 2000

4 Hoe J, "Use of the QOL-AD for measuring quality of life in people with severe dementia–The LASER-AD study" 34 : 130-135, 2005

5 Hoffman A, "The prevalence of dementia in Europe: a collaborative study of 1980-1990 findings" 20 : 734-748, 1991

6 Burgener S, "Relationships among caregiver factors and quality of life in care recipients with irreversible dementia" 16 : 88-102, 2002

7 Whitehouse PJ, "Quality-of-Life assessment in dementia drug development. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines" 11 : 56-60, 1997

8 Whitehouse PJ, "Quality of life in dementia: ten years later" 17 : 199-200, 2003

9 Logsdon RG, "Quality of life in Alzheimer’s disease: patient and caregiver reports" 5 : 21-32, 1999

10 Small GW, "Diagnosis and treatment of Alzheimer disease and related disorders: Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer’s Association, and the American Geriatrics Society" 267 : 1363-1371, 1997

11 Brod m, "Conceptualization and measurement of quality of life in dementia: the dementia quality of life instrument (DQOL)" 39 : 25-35, 1999

12 Logsdon RG, "Assessing quality of life in Alzheimer’s disease: Conceptual and methodological issues" 5 : 3-6, 1999