폐결핵 환자로부터 분리된 결핵균의 각종 항결핵제에 대한 감수성에 관한 연구 = Drug Resistance of Mycobacterium tuberculosis Isolated from Patients with Pulmonary Tuberculosis

다국어 초록 (Multilingual Abstract)

Drug resistance, whether acquired as a result of inappropriate or inadequate chemotherapy or from an individual whose organism was drug resistant, may present serious obstacles to the eradication of tuberculosis.
The authors attempted direct drug susceptibility test to various primary and second line antitubereulosis drugs on 139 isolates from pulmonary tuberculosis patients who have been hospitalized at National Kongju Hospital for tuberculosis.
The results were summarized as follows;
1. Out of 101 tuberculosis patients, male patients were slightly more than female as a ratio of 1.59: 1 and the average age of onset was 30 years.
2. The number of patients who have been suffered from pulmonary tuberculosis more than 6 years was 61 (60.4%).
3. A11 of 139 isolated tubercle bacilii were resistant to one or more antituberculosis drugs.
4. Out of 139 isolates, 94.2% was resistant to INH, 89.2% to EMB, 75.5% to SM, 63.3% to PZA, 56.1% to RMP,47.5% to KM, 42.4% to PAS, 27.3% to CS, 16.5% to PTA and 2.9% to TUM.
5. Resistances to INH-SM-PAS, INH-SM-EMB, INH-SM-RMP, INH-EMB-RMP, PTA-PZA-CS and INH-SM-TUM were 36.0%, 69.1%, 41.0%, 46.8%, 7.2% and 2.9%, respectively.
6. Resistances to INH-EMB-RMP-PZA and INH-SM-RMP-PZA were 31.7% and 27.3%, respectively.