증례 : 소화기 ; Propofol을 사용한 수면내시경 후 발생한 아나필락시스 1예 = Case Reports : Gastroenlerology ; A case of propofol-induced anaphylaxis

국문 초록 (Abstract)

프로포폴은 수면내시경 검사 시행 시 진정유도를 위해 널리 쓰이는 약제로 이로 인한 호흡계 및 순환계 억제에 대해서는 잘 알려져 있으나 아나필락시스는 드물다. 저자들은 약제에 대한 알레르기의 병력이 없는 환자에서 프로포폴을 사용한 수면내시경 후 피부발진, 소양감, 호흡곤란 및 저혈압등의 증상이 발생한 1예를 경험하였다. 피부단자시험이나 혈청 특이 IgE 항체를 측정하지 못하였으나, 다른 약제나 라텍스 장갑의 사용 없이 프로포폴 단독 투여 후 발생하여 프로포폴 유발성 아나필락시스로 진단하였고, 이를 문헌고찰과 함께 보고하는 바이다.

다국어 초록 (Multilingual Abstract)

Propofol is widely used for sedation during endoscopy. Hemodynamic compromise and respiratory depression might occur under propofol sedation, whereas anaphylaxis is rare. We recently experienced this rare side effect. A 71-year-old woman suffering from substernal chest discomfort underwent endoscopic examination under propofol sedation. She denied any history of allergic reaction to drugs or foods such as beans and eggs. After completion of the endoscopic examination, she developed a whole-body rash with pruritus and edema of her face, including the eyelids and lips. Hypotension was seen on physical examination, and her oxygen saturation was decreased on pulse oximetry. She recovered completely after treatment with epinephrine, an antihistamine, and steroids, with supportive care. Anaphylaxis to propofol is a rare side effect, and prompt treatment is mandatory when it develops. (Korean J Med 79:549-552, 2010)

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