急性 Ethyl Alcohol 中毒이 四鹽化炭素에 依한 急性 中毒時 肝의 細胞病理學的 變化에 미치는 影響에 關한 硏究 = Cytopathological Effects of Acute Alcohol Intoxication on the Acute Hepatotoxicity Induced by Carbon Tetrachloride

다국어 초록 (Multilingual Abstract)

In order to study the cytopathological effects of acute alcohol intoxication on the acute hepatotoxie cellular changes induced by carbon tetrachloride, the control animals, the Sprague-Dawley rats were administered with 0.6ml/kg of carbon tetrachloride by intraperitoneal injection and the experimental animals were intoxicated with 1ml, 2ml, 3ml, 4ml, 5ml, and 6ml/kg of ethyl alcohol for 3 consecutive days before carbon tetrachloride administration.
The mortality and cytopathological changes in the control and experimental groups were as follows :
1. The mortality of the control group was 16.6%, and those of the experimental groups intoxicated with 3ml, 6ml, 9ml, 12ml, 1.5ml, and 18ml/kg of ethyl alcohol were 25.0%, 25.0%, 50.0%, 62.5%, 91.6%, and 100%, respectively.
It is evident that the larger doses of ethyl alcohol intoxicated, the higher mortality in the experimental animals showed. Those intoxicated with 18ml/kg of ethyl alcohol died within 48 experimental hours.
2. Vacuolar degeneration and fatty change of the hepatic cells in the control group showed mild to moderate within 52 experimental hours and disappeared thereafter.
The changes in the 3ml, 6ml and 9ml group showed more marked in degree and longer duration that the control, but those changes in the 15ml and 18ml group showed milder than the control group.
3. The necrotic changes of the hepatic lobules in the control group showed mild to moderate degree within 52 experimental hours, and disappeared thereafter.
Those necrotoxic changes in the experimental groups showed more severe in degree and lasted longer than the control.
4. Regeneration of hepatic cells and sinusoidal cells, and reconstruction of the he patic lobules in the control group showed moderately and marked active from 48 to 52 experimental hours, and achieved almost normal structure by 72 experimental hours., whereas those regenerative changes in the experimental groups appeared more slowly and milder in degree than the control.
Those changes were more evident in the groups intoxicated with larger dose of ethyl alcohol.
5. The above results suggest that the mortality of the experimental animals and necrotoxic changes of the liver cells showed higher incidence, and more marked and extensive in the experimental groups in dose related order, and were more prominent in the experimental groups intoxicated with larger dose of ethyl alcohol, e. g. , 15ml and 18ml groups. The regenerative changes of the hepatic and sinusoidal cells, and reconstruction of the hepatic lobules were less achieved in experimental groups, especially in the groups intoxicated with larger dose, e. g. , 15ml and 18ml/kg of ethyl alcohol.