Effect of grafted alkyl groups on aggregation behavior of amphiphilic poly(aspartic acid) = Effect of grafted alkyl groups on aggregation behavior of amphiphilic poly(aspartic acid)

다국어 초록 (Multilingual Abstract)

Biodegradable amphiphilic poly(aspartic acid) (PASP) derivatives containing long alkyl chains were synthesized by thermal condensation, aminolysis by alkylamine, and followed by hydrolysis of remaining succinimide units in polymer backbone. PASP with long alkyl chains formed self-aggregates by ultrasonication and physicochemical properties of self-aggregates were analyzed. Strong hydrophobic interaction by higher amount of grafted alkyl chains induced higher aqueous stability of self-aggregates. Bending of stiff PASP backbone and strong association of alkyl chains were considered to be major factors for determining aqueous stability. Critical aggregation concentration showed linear relationship with degree of substitution of alkyl chains.