고콜레스테롤 혈증은 힘줄의 지방축적, 피부, 간비대, 췌장염 및 심장 발작 등과 같은 여러 가지 병리현상을 나타낸다. 본 연구는 홍삼 물추출물(홍삼정)이 고콜레스테롤로 식이된 마우스의 ...
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https://www.riss.kr/link?id=A76327478
2008
Korean
KCI등재,SCIE,SCOPUS
학술저널
283-290(8쪽)
12
학회 요청에 의해 무료로 제공
0
상세조회0
다운로드국문 초록 (Abstract)
고콜레스테롤 혈증은 힘줄의 지방축적, 피부, 간비대, 췌장염 및 심장 발작 등과 같은 여러 가지 병리현상을 나타낸다. 본 연구는 홍삼 물추출물(홍삼정)이 고콜레스테롤로 식이된 마우스의 ...
고콜레스테롤 혈증은 힘줄의 지방축적, 피부, 간비대, 췌장염 및 심장 발작 등과 같은 여러 가지 병리현상을 나타낸다. 본 연구는 홍삼 물추출물(홍삼정)이 고콜레스테롤로 식이된 마우스의 간 기능 회복에 대하여 연구하였다. 고콜레스테롤 사료를 2주 동안 식이 한 후 홍삼물추출물(홍삼정)을 투여용량 100,300,500 mg/kg, b.w으로 경구 투여하였다. 마우스군을 6개 군으로, 즉, 정상군(AIN-2WK), 고콜레스테롤 4주 식이군(CHOL-4WK), 고콜레스테롤 2주 식이 + 정상식이 2주군 (CHOL-2WK) 그리고 고콜레스테롤 2주식이 + 정상식이 2주 및 홍삼 물추출물 투여군( R1OO, R300, R500) 으로 나누어 실험하였다.
1. 홍삼 투여군의 간 무게 및 총 지질의 양은 고콜레스테롤 4주 식이군(CHOL-4WK) 및 고콜레스테롤 2주 식이군 (CHOL-2WK) 비하여 현저하게 낮았다. 그러므로 홍삼 물추출물은 효과는 고콜레스테롤 식이한 생쥐의 간의 비대 억제함을 알 수 있었다.
2. 콜레스테롤 2주 식이군(CHOL-2WK)은 고콜레스테롤 식이군(CHOL-4WK)에 비하여 총 콜레스테롤 및 HDL-콜레스테롤이 유의적으로 감소하였다. 이러한 감소 효과는 홍삼 물추출물 투여에 의하여 더욱 강화되었다.
3. 고콜레스테롤 4주 식이군(CHOL-4WK)은 정상권(AIN-2WK)에 비하여 유의하게 간 중성 지방이 감소하였으며 콜레스테롤 2주 식이군(CHOL-2WK) 및 홍삼 물추출물 투여군은 유의하게 증가하였다. 이결과로 볼때 정상식이 전환 및 홍삼 투여가 간기능을 정상화 시킴을 알 수 있었다.
4. 홍삼 투여군에서 지질과산화의 수치가 현저하게 감소하였다.
이러한 결과들은 홍삼 물추출물은 고콜레스테롤혈증이 유발된 마우스에서 간의 지질 대사 및 간 기능을 증진시킴으로써 비만의 식이요법 및 고콜레스테롤 혈증에 유용할 것으로 생각된다.
다국어 초록 (Multilingual Abstract)
Hypercholesterolemia is associated with many pathological states such as fat deposit in the tendon and skin, hepatomegaly, pancreatitis and heart attack. The present study was focused on the effect of Korean red ginseng water extract (RGWE) on the rec...
Hypercholesterolemia is associated with many pathological states such as fat deposit in the tendon and skin, hepatomegaly, pancreatitis and heart attack. The present study was focused on the effect of Korean red ginseng water extract (RGWE) on the recovery of hepatic function that was deteriorated in high-cholesterol diet fed mice. Mice were divided into 6 groups; normal diet group (AIN-2WK), 4 week-high-cholesterol diet group (CHOL-4WK), 2 week-highcholesterol + 2 week-normal diet group (CHOL-2WK), 2 week-high-cholesterol + 2 week-normal diet + RGWE treated group (R100, R300, R500). RGWE treated group received normal diet and RGWE at daily doses of 100, 300, 500 mg/kg b.w. for 2 weeks after the 2 weeks feeding of high-cholesterol diet. The results are as follows: 1. The hepatic weight and total hepatic lipid weight were markedly lower in RGWE treated group than those in the CHOL-4WK or CHOL-2WK group, indicating that ginseng inhibited hepatic hypertrophy. 2. Total hepatic cholesterol and HDL-cholesterol in normal diet conversion group (CHOL-2WK) were significantly reduced compared with the high cholesterol group (CHOL-4WK). The lowering effect was significantly reinforced by RGWE administration. 3. Hepatic triglyceride level of CHOL-4WK group was markedly lower than that of the normal group (AIN-2WK). However, the level was significantly increased in CHOL-2WK and RGWE treated group. The result indicated that ginseng administration and diet conversion exert nonnalizing effects of hepatic function. 4. The lipid peroxide levels in RGWE treated groups were markedly lower than CHOL-2WK group. These results suggest that Korean red ginseng water extract can be useful as a dietary supplement for the treatment of obesity or hypercholesterolemia by improving lipid metabolism and hepatic function.
참고문헌 (Reference)
1 Coleman, C. I. J., "The effect of Panax ginseng in quality of life" 28 : 5-15, 2003
2 Yamamoto, M., "Serum HDL-cholesterol-incresing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man" 11 : 96-101, 1983
3 Lowry, O. H., "Protein measurement with the Folin-Phenol reagents" 193 : 265-275, 1951
4 Gallou., G., "Plasma Malondialdehyde in type 1 and type 2 diabetic patients" 214 (214): 227-234, 1993
5 Cui, X., "Orally administered ginseng decreases platelet adhesiveness in 66% hepatectomized rats" 27 : 251-256, 1998
6 Remirez, M., "Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocyte" 293 : 301-308, 1995
7 Hayek, T., "Macrophage NADPH oxidase activation ipared cholesterol fluxes, and incresed cholesterol biosynthesis in diabetic mice : A stimulatory role for D-glucose" 9804 : 1-10, 2007
8 Inoue, M., "Lipoprotein lipase activation by red ginseng saponins in hyperlipidemia model animals" 6 : 257-265, 1999
9 Polavarapu, R., "Increased Lipid peroxidation and Imparied Antioxidant Enzyme Function is Associated with Pathlological Liver Injury in Experimental Alcholic liver Diease in Rats Fed Diets High in Corn oil and Fish oil" 27 : 1317-1323, 1998
10 Bansal, S. K., "High pressure liquid chromatographic separation of multiful forms of cytochrome P-450" 117 : 268-274, 1983
1 Coleman, C. I. J., "The effect of Panax ginseng in quality of life" 28 : 5-15, 2003
2 Yamamoto, M., "Serum HDL-cholesterol-incresing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man" 11 : 96-101, 1983
3 Lowry, O. H., "Protein measurement with the Folin-Phenol reagents" 193 : 265-275, 1951
4 Gallou., G., "Plasma Malondialdehyde in type 1 and type 2 diabetic patients" 214 (214): 227-234, 1993
5 Cui, X., "Orally administered ginseng decreases platelet adhesiveness in 66% hepatectomized rats" 27 : 251-256, 1998
6 Remirez, M., "Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocyte" 293 : 301-308, 1995
7 Hayek, T., "Macrophage NADPH oxidase activation ipared cholesterol fluxes, and incresed cholesterol biosynthesis in diabetic mice : A stimulatory role for D-glucose" 9804 : 1-10, 2007
8 Inoue, M., "Lipoprotein lipase activation by red ginseng saponins in hyperlipidemia model animals" 6 : 257-265, 1999
9 Polavarapu, R., "Increased Lipid peroxidation and Imparied Antioxidant Enzyme Function is Associated with Pathlological Liver Injury in Experimental Alcholic liver Diease in Rats Fed Diets High in Corn oil and Fish oil" 27 : 1317-1323, 1998
10 Bansal, S. K., "High pressure liquid chromatographic separation of multiful forms of cytochrome P-450" 117 : 268-274, 1983
11 Pan, S. Y., "High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice:animal models of acute hypertriglyceridemia" 27 : 673-678, 2006a
12 Kim, S. H., "Effects of panax extract on lipid metabolism in human" 48 : 511-513, 2003
13 Park, S. C., "Effect of ginseng components on content of cholesterol and activity of Acyl CoA : cholesterol acyltransterase in Hep G2 cells cultured in cholesterol rich medium" 19 (19): 212-218, 1995
14 Kang, J. A., "Effect of garlic and onion on plasma an liver cholesterol and triglyceride and platelet aggregation in rats basal or cholesterol supplemented diets" 32 : 132-138, 1997
15 Turley, E., "Effect of cholesterol feeding on DNA damage in male and femail syrian hamsters" 43 : 47-51, 1999
16 Yang, Y., "Effect of aerobic exerciseand ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice" 20 : 563-565, 1999
17 Rhee, S. J., "Change of lipid concentration and histochemical observation in liver of rat fed high fat diet" 17 : 113-125, 1984
18 Yoon, S. H., "Cellular distribution and metabolism in rat liver" 17 (17): 114-122, 1993
19 Pan, S. Y., "Bifendate treatment attenuates steatosis in cholesterol/bile salt and high fat diet-induced hypercholesterolemia in mice" 552 : 170-175, 2006b
20 Kwon, B.M., "Acyl-CoA : cholesterol acyltransferase inhibitory activity of ginseng sapogenins,produced from the ginseng saponins" 9 : 1375-1378, 1999
21 Matsuda, H., "Activation of acyl-coenzyme A : cholesterol acyltransferase activity by cholesterol is not due to altered mRNA levels in HepG2 cells" 13 (13): 76-84, 1996
22 Folch, J., "(1957): Stanley, A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissues" 226 : 497-509, 1951
랫드에서 TCDD 투여에 의해 유도된 생체독성의 고려홍삼 추출물에 의한 억제 효과
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-04-07 | 학술지명변경 | 한글명 : 고려인삼학회지 -> Journal of Ginseng Research | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 3.97 | 1.04 | 2.93 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
2.49 | 2.07 | 1.604 | 0.15 |