Comparing the cytotoxic effect of light-emitting and organic light-emitting diodes based light therapy on human adipose-derived stem cells

다국어 초록 (Multilingual Abstract)

Light has attracted significant attention as a promising tool in the biomedical and cosmetic industries.
However, little is known about the cytotoxic effects of conventional light sources based on their physicaleffects such as temperature and luminance. Here, the cytotoxic effects of representative light sources, alight-emitting diode (LED) and an organic light-emitting diode (OLED), were studied with humanadipose-derived stem cells (hADSCs). Regardless of the identical light energy conditions, LED groupinduced a higher apoptotic activity in hADSCs than the OLED group due to its significant heat generationcompared to OLED as further demonstrated with heat shock protein family gene expression. Additionally,we further confirmed the effect of luminance by irradiating light from LED and OLED under the sametemperature and energy conditions. Increased cell proliferation was confirmed in the OLED group, anda significant expression of intracellular reactive oxygen species was observed in the LED group withoutshowing heat shock protein upregulation. Taken together, the differences in cytotoxicity and cellularresponse after LED irradiation compared with OLED irradiation can be varied with temperature and luminancecontrol. This study suggests that OLED based device could be an alternative and promising lightsource for future biomedical and cosmetic applications.

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