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다국어 초록 (Multilingual Abstract)

Novel oxadiazoles bearing 5-phenyl-tetrazole (5a–k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3, and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a–k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole–tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics.

참고문헌 (Reference)

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2 S. Rozen, 132 : 365-, 2000

3 A. Daroszewska, 2 : 270-, 2006

4 B. K. Park, 13 : 62-, 2007

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7 J. Bostrom, 55 : 1817-, 2012

8 D. M. Cottrell, 12 : 2815-, 2004

9 R. M. Jones, 19 : 1339-, 2009

10 S. H. Lee, 51 : 7216-, 2008

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2 S. Rozen, 132 : 365-, 2000

3 A. Daroszewska, 2 : 270-, 2006

4 B. K. Park, 13 : 62-, 2007

5 J. A. Cirelli, 16 : 426-, 2009

6 W. J. Boyle, 423 : 337-, 2003

7 J. Bostrom, 55 : 1817-, 2012

8 D. M. Cottrell, 12 : 2815-, 2004

9 R. M. Jones, 19 : 1339-, 2009

10 S. H. Lee, 51 : 7216-, 2008

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44 "NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy"

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연월일	이력구분	이력상세
2023	평가예정	해외DB학술지평가 신청대상 (해외등재 학술지 평가)
2020-01-01	평가	등재학술지 유지 (해외등재 학술지 평가)
2008-01-01	평가	SCI 등재 (기타)
2006-01-01	평가	등재학술지 유지 (등재유지)
2004-01-01	평가	등재학술지 유지 (등재유지)
2001-07-01	평가	등재학술지 선정 (등재후보2차)
1998-01-01	평가	등재후보학술지 선정 (신규평가)